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PreprintCC BYChemRxiv

Hydroxyurea synthesis using resonant acoustic mixing in ethanol

  • Yousra Hamdane1
  • Felix Polyak1,2
  • William D. Lubell1
  1. 1Département de Chimie, Complexe des Sciences, B-3015, 1375 Avenue Thérèse-Lavoie-Roux Montréal, Québec, Canada, H2V 0B3
  2. 2Studio Bioscience Inc., 111 Rue Terry Fox, Verdun, QC, H3E 1L4
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Abstract

Hydroxyurea derivatives have important medicinal utility acting as enzyme inhibitors and anticancer agents. Their syntheses have, however, entailed low yielding routes employing long reaction times and toxic reagents such as phosgene. Towards sustainable and environmentally benign hydroxyurea synthesis, a one-step hydroxycarbamoylation approach is described employing resonant acoustic mixing (RAM) to expedite reactions at higher concentration. Eighteen medicinally relevant hydroxyurea were synthesized in 68-91% yields using ethanol as green solvent.

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Cite

BibTeXRIS
BibTeX
@misc{hamdane2026hydroxyurea,
  title = {{Hydroxyurea synthesis using resonant acoustic mixing in ethanol}},
  author = {Yousra Hamdane and Felix Polyak and William D. Lubell},
  howpublished = {ChemRxiv},
  year = {2026},
  month = oct,
  doi = {10.26434/chemrxiv.15010860/v1},
  url = {https://chemrxiv.org/doi/full/10.26434/chemrxiv.15010860/v1},
  note = {CC BY},
}
RIS
TY  - UNPB
TI  - Hydroxyurea synthesis using resonant acoustic mixing in ethanol
AU  - Yousra Hamdane
AU  - Felix Polyak
AU  - William D. Lubell
PY  - 2026
DA  - 2026/10/22
PB  - ChemRxiv
DO  - 10.26434/chemrxiv.15010860/v1
UR  - https://chemrxiv.org/doi/full/10.26434/chemrxiv.15010860/v1
AB  - Hydroxyurea derivatives have important medicinal utility acting as enzyme inhibitors and anticancer agents. Their syntheses have, however, entailed low yielding routes employing long reaction times and toxic reagents such as phosgene. Towards sustainable and environmentally benign hydroxyurea synthesis, a one-step hydroxycarbamoylation approach is described employing resonant acoustic mixing (RAM) to expedite reactions at higher concentration. Eighteen medicinally relevant hydroxyurea were synthesized in 68-91% yields using ethanol as green solvent.
ER  -