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PreprintCC BYChemRxiv

AlCl3-Mediated Arylation of Dimethyl 2-Arylcyclopropane-1,1dicarboxylates with Benzene: A Facile Approach to Dimethyl 2-(2-Aryl-2-phenylethyl)malonates

  • Aidar B. Yulbarisov
  • Tat’yana P. Zosim
  • Rita N. Kadikova
  • Ilfir R. Ramazanov
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Abstract

It was found that the reaction of dimethyl 2-arylcyclopropane-1,1-dicarboxylates with benzene in the presence of two equivalents of AlCl3 at room temperature (23 o C) for 1 h leads to the selective opening of the three-membered ring with the formation of dimethyl 2-(2-aryl-2-phenylethyl)malonates in high yields (89-94%). The developed method demonstrates high tolerance toward both electron-donating (4-Me) and electron-withdrawing (4-Cl) substituents on the aryl ring of the starting cyclopropane, providing a simple and effective route to the synthesis of substituted malonates.

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Cite

BibTeXRIS
BibTeX
@misc{yulbarisov2026alcl3mediated,
  title = {{AlCl3-Mediated Arylation of Dimethyl 2-Arylcyclopropane-1,1dicarboxylates with Benzene: A Facile Approach to Dimethyl 2-(2-Aryl-2-phenylethyl)malonates}},
  author = {Aidar B. Yulbarisov and Tat’yana P. Zosim and Rita N. Kadikova and Ilfir R. Ramazanov},
  howpublished = {ChemRxiv},
  year = {2026},
  month = aug,
  doi = {10.26434/chemrxiv.15008078/v1},
  url = {https://chemrxiv.org/doi/full/10.26434/chemrxiv.15008078/v1},
  note = {CC BY},
}
RIS
TY  - UNPB
TI  - AlCl3-Mediated Arylation of Dimethyl 2-Arylcyclopropane-1,1dicarboxylates with Benzene: A Facile Approach to Dimethyl 2-(2-Aryl-2-phenylethyl)malonates
AU  - Aidar B. Yulbarisov
AU  - Tat’yana P. Zosim
AU  - Rita N. Kadikova
AU  - Ilfir R. Ramazanov
PY  - 2026
DA  - 2026/08/31
PB  - ChemRxiv
DO  - 10.26434/chemrxiv.15008078/v1
UR  - https://chemrxiv.org/doi/full/10.26434/chemrxiv.15008078/v1
AB  - It was found that the reaction of dimethyl 2-arylcyclopropane-1,1-dicarboxylates with benzene in the presence of two equivalents of AlCl3 at room temperature (23 o C) for 1 h leads to the selective opening of the three-membered ring with the formation of dimethyl 2-(2-aryl-2-phenylethyl)malonates in high yields (89-94%). The developed method demonstrates high tolerance toward both electron-donating (4-Me) and electron-withdrawing (4-Cl) substituents on the aryl ring of the starting cyclopropane, providing a simple and effective route to the synthesis of substituted malonates.
ER  -