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Peer-reviewedCC BY-NC-NDAlzheimer's & dementia (Amsterdam, Netherlands)

Fluctuations correlates in advanced dementia with Lewy bodies: A longitudinal study.

  • Melissa J Armstrong1,2
  • Tingchang Wang3
  • Tracy Tholanikunnel1,2
  • Hannah Jury1
  • Kaitlin Sovich1
  • Susan M Maixner4
  • Abhimanyu Mahajan5
  • Zhigang Li3
5 affiliations
  1. 1Department of Neurology University of Florida College of Medicine Gainesville Florida USA.
  2. 2Norman Fixel Institute for Neurological Diseases Gainesville Florida USA.
  3. 3Department of Biostatistics University of Florida College of Medicine Gainesville Florida USA.
  4. 4Department of Psychiatry University of Michigan Ann Arbor Michigan USA.
  5. 5Department of Neurology & Rehabilitation Medicine University of Cincinnati Cincinnati Ohio USA.
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Abstract

Cognitive fluctuations are a core feature of dementia with Lewy bodies (DLB). Research focuses largely on early stages. We investigated fluctuation frequency and correlates in advanced DLB. The Mayo Fluctuations Scale and Clinician Assessment of Fluctuations measured fluctuations. Analyses assessed frequency, scale correlations, and experiences correlating with baseline and longitudinal fluctuations. Fluctuations occurred in > 70% of the cohort across visits. Fluctuation scales correlated very weakly. Baseline fluctuations correlated with female sex, symptom burden, cognitive severity, neuropsychiatric symptom burden, hallucinations, sleepiness/alertness, parkinsonism, autonomic symptom burden, and orthostatic hypotension. Additional variables correlated with single scales. Fluctuations weakly correlated with participant quality of life and caregiver experiences. Longitudinal fluctuations correlated with other DLB features, comorbidities, and medication burden. Fluctuations are common in advanced DLB and correlate with other symptoms. Fluctuation measurement requires further conceptual and psychometric work for best approaches, including for screening and longitudinal assessments and treatment trials. NCT04829656.

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Cite

BibTeXRIS
BibTeX
@article{armstrong2026fluctuations,
  title = {{Fluctuations correlates in advanced dementia with Lewy bodies: A longitudinal study.}},
  author = {Melissa J Armstrong and Tingchang Wang and Tracy Tholanikunnel and Hannah Jury and Kaitlin Sovich and Susan M Maixner and Abhimanyu Mahajan and Zhigang Li},
  journal = {Alzheimer's \& dementia (Amsterdam, Netherlands)},
  year = {2026},
  month = oct,
  doi = {10.1002/dad2.70519},
  url = {https://europepmc.org/article/MED/42953268},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - Fluctuations correlates in advanced dementia with Lewy bodies: A longitudinal study.
AU  - Melissa J Armstrong
AU  - Tingchang Wang
AU  - Tracy Tholanikunnel
AU  - Hannah Jury
AU  - Kaitlin Sovich
AU  - Susan M Maixner
AU  - Abhimanyu Mahajan
AU  - Zhigang Li
PY  - 2026
DA  - 2026/10/27
JO  - Alzheimer's & dementia (Amsterdam, Netherlands)
DO  - 10.1002/dad2.70519
UR  - https://europepmc.org/article/MED/42953268
AB  - Cognitive fluctuations are a core feature of dementia with Lewy bodies (DLB). Research focuses largely on early stages. We investigated fluctuation frequency and correlates in advanced DLB. The Mayo Fluctuations Scale and Clinician Assessment of Fluctuations measured fluctuations. Analyses assessed frequency, scale correlations, and experiences correlating with baseline and longitudinal fluctuations. Fluctuations occurred in > 70% of the cohort across visits. Fluctuation scales correlated very weakly. Baseline fluctuations correlated with female sex, symptom burden, cognitive severity, neuropsychiatric symptom burden, hallucinations, sleepiness/alertness, parkinsonism, autonomic symptom burden, and orthostatic hypotension. Additional variables correlated with single scales. Fluctuations weakly correlated with participant quality of life and caregiver experiences. Longitudinal fluctuations correlated with other DLB features, comorbidities, and medication burden. Fluctuations are common in advanced DLB and correlate with other symptoms. Fluctuation measurement requires further conceptual and psychometric work for best approaches, including for screening and longitudinal assessments and treatment trials. NCT04829656.
SN  - 2352-8729
ER  -