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PreprintCC BY-NC-NDbioRxiv

Genetics and genomics of enteroarthroconidial development in Coccidioides

  • K. E. Fleming
  • K. C. Christensen
  • E. Szewczyk
  • C. M. Homer
  • R. B. Brem1
  1. 1University of California, Berkeley
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Abstract

The human fungal pathogen Coccidioides causes disease when its infectious spores, enteroarthroconidia, are inhaled from the soil. Spore dispersal depends on the death of a unique developmental form, disjunctor cells, which flank incipient enteroarthroconidia and are unexplored molecularly. Here we used single-cell (sc) RNA-seq to catalog expression across the Coccidioides colony; with gene deletion and protein tagging, we established a role for the pyropoptosis-like cell death pathway in enteroarthroconidial development.

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Cite

BibTeXRIS
BibTeX
@misc{fleming2026genetics,
  title = {{Genetics and genomics of enteroarthroconidial development in Coccidioides}},
  author = {K. E. Fleming and K. C. Christensen and E. Szewczyk and C. M. Homer and R. B. Brem},
  howpublished = {bioRxiv},
  year = {2026},
  month = oct,
  doi = {10.64898/2026.10.27.762035},
  url = {https://www.biorxiv.org/content/10.64898/2026.10.27.762035v1},
  note = {CC BY-NC-ND},
}
RIS
TY  - UNPB
TI  - Genetics and genomics of enteroarthroconidial development in Coccidioides
AU  - K. E. Fleming
AU  - K. C. Christensen
AU  - E. Szewczyk
AU  - C. M. Homer
AU  - R. B. Brem
PY  - 2026
DA  - 2026/10/27
PB  - bioRxiv
DO  - 10.64898/2026.10.27.762035
UR  - https://www.biorxiv.org/content/10.64898/2026.10.27.762035v1
AB  - The human fungal pathogen Coccidioides causes disease when its infectious spores, enteroarthroconidia, are inhaled from the soil. Spore dispersal depends on the death of a unique developmental form, disjunctor cells, which flank incipient enteroarthroconidia and are unexplored molecularly. Here we used single-cell (sc) RNA-seq to catalog expression across the Coccidioides colony; with gene deletion and protein tagging, we established a role for the pyropoptosis-like cell death pathway in enteroarthroconidial development.
ER  -