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Peer-reviewedCC BYMicroorganisms

Primary Native Bile Culture Patterns Collected During ERCP: Microbial Profiles in Malignant Versus Benign Biliary Obstruction.

  • Szu-Yao Wang1
  • Chun Yang1
  • Chun-Fang Tung1,2
  • Yi-Jun Liao1,2
  • Chia-Chang Chen1,2
  • Yen-Chun Peng1,2,3
  1. 1Division of Gastroenterology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung 407219, Taiwan.
  2. 2School of Medicine, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan.
  3. 3Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung 402202, Taiwan.
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Abstract

Acute biliary tract infection is a serious complication of biliary obstruction, and understanding the native biliary microbiota is essential for optimizing empirical antimicrobial therapy. We retrospectively reviewed 404 patients who underwent their first endoscopic retrograde cholangiopancreatography (ERCP) for biliary obstruction between January and December 2024; bile was aspirated before any therapeutic manipulation, and microbiological characteristics were compared between benign and malignant obstruction. Among 404 patients, 365 bile samples were collected, and overall culture positivity was 68.8%. Benign obstruction demonstrated significantly higher positivity than malignant obstruction (71.9% vs. 59.3%, p = 0.04). Monomicrobial Gram-positive organisms were disproportionately more common in benign obstruction (17.2% vs. 7.7%, p = 0.03), whereas monomicrobial fungal organisms were more frequently isolated in malignant obstruction (9.9% vs. 4.4%, p = 0.07). Polymicrobial infections occurred in approximately one-quarter of cases, and anaerobes were relatively uncommon (7.9%). Bile cultures obtained during the initial ERCP revealed distinct microbial profiles associated with different etiologies of biliary obstruction, suggesting that the distribution of identified organisms varies according to the underlying cause of obstruction.

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Cite

BibTeXRIS
BibTeX
@article{wang2026primary,
  title = {{Primary Native Bile Culture Patterns Collected During ERCP: Microbial Profiles in Malignant Versus Benign Biliary Obstruction.}},
  author = {Szu-Yao Wang and Chun Yang and Chun-Fang Tung and Yi-Jun Liao and Chia-Chang Chen and Yen-Chun Peng},
  journal = {Microorganisms},
  year = {2026},
  month = sep,
  doi = {10.3390/microorganisms14102128},
  url = {https://europepmc.org/article/MED/42943368},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Primary Native Bile Culture Patterns Collected During ERCP: Microbial Profiles in Malignant Versus Benign Biliary Obstruction.
AU  - Szu-Yao Wang
AU  - Chun Yang
AU  - Chun-Fang Tung
AU  - Yi-Jun Liao
AU  - Chia-Chang Chen
AU  - Yen-Chun Peng
PY  - 2026
DA  - 2026/09/22
JO  - Microorganisms
DO  - 10.3390/microorganisms14102128
UR  - https://europepmc.org/article/MED/42943368
AB  - Acute biliary tract infection is a serious complication of biliary obstruction, and understanding the native biliary microbiota is essential for optimizing empirical antimicrobial therapy. We retrospectively reviewed 404 patients who underwent their first endoscopic retrograde cholangiopancreatography (ERCP) for biliary obstruction between January and December 2024; bile was aspirated before any therapeutic manipulation, and microbiological characteristics were compared between benign and malignant obstruction. Among 404 patients, 365 bile samples were collected, and overall culture positivity was 68.8%. Benign obstruction demonstrated significantly higher positivity than malignant obstruction (71.9% vs. 59.3%, p = 0.04). Monomicrobial Gram-positive organisms were disproportionately more common in benign obstruction (17.2% vs. 7.7%, p = 0.03), whereas monomicrobial fungal organisms were more frequently isolated in malignant obstruction (9.9% vs. 4.4%, p = 0.07). Polymicrobial infections occurred in approximately one-quarter of cases, and anaerobes were relatively uncommon (7.9%). Bile cultures obtained during the initial ERCP revealed distinct microbial profiles associated with different etiologies of biliary obstruction, suggesting that the distribution of identified organisms varies according to the underlying cause of obstruction.
SN  - 2076-2607
ER  -