Effects of muscle strength training with blood flow restriction on glomerular function in people with stage 3 chronic kidney disease.
6 affiliations
- 1Universidade Federal de Alagoas, Instituto de Educação Física e Esporte, Maceió, AL, Brazil.
- 2Universidade Federal da Paraíba, João Pessoa, PB, Brazil.
- 3Universidade Federal de Alagoas, Hospital Universitário Professor Alberto Antunes, Maceió, AL, Brazil.
- 4Universidade Federal de Alagoas, Maceió, AL, Brazil.
- 5Universidade Federal de Alagoas, Faculdade de Medicina, Maceió, AL, Brazil.
- 6Universidade Regional do Cariri, Curso de Educação Física, Crato, CE, Brazil.
Abstract
Introduction
Stage 3 chronic kidney disease (CKD) represents a critical juncture in clinical management. However, muscle strength training (MST) combined with blood flow restriction (BFR) has shown benefits as an adjunctive treatment, but its renal effects remain unclear.Objective
To analyze the effects of MST+BFR on markers of glomerular function in individuals with CKD-3.Method
A randomized, longitudinal clinical trial with 40 participants divided into 4 groups: control (G1); low-load MST (G2); high-load MST (G3); and low-load MST combined with BFR (G4). Serum creatinine, cystatin C, microalbuminuria, and estimated eGFR were used as dependent variables. The MST protocol was conducted over 12 weeks, 3 times per week, for 30-40 minutes, with 3 exercises (single- and multi-joint) per day at progressive intensities. Data analysis (intention-to-treat) was performed using the Shapiro-Wilk test (normality), paired t-test/Wilcoxon test (within-group comparisons), ANOVA/Kruskal-Wallis tests (between-group comparisons), Bonferroni test (post hoc corrections), and Cohen's d (effect size) with a p-value ≤ 0.05.Results
The participants were predominantly male (52.5%) with low levels of physical activity (60%), hypertension (87.5%), and some with diabetes (37.5%). Group 4 showed a significant increase in albuminuria levels (p = 0.048), as well as significant differences compared with Group 1 (creatinine, p = 0.032) and Group 2 (creatinine, p = 0.036; and eGFR-Cr, p = 0.032).Conclusion
MST+BFR was not associated with severe adverse effects on serum creatinine/cystatin C levels, eGFR estimates, or urinary creatinine and microalbuminuria levels, but it may significantly increase albuminuria levels.
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BibTeX
@article{caetano2026effects,
title = {{Effects of muscle strength training with blood flow restriction on glomerular function in people with stage 3 chronic kidney disease.}},
author = {Antonio Filipe Pereira Caetano and Janyeliton Alencar de Oliveira and Amaro Wellington da Silva and Cyro Rego Cabral Junior and Michelle Jacintha Oliveira Cavalcante and Maria do Socorro Cirilo-Sousa},
journal = {Jornal brasileiro de nefrologia},
year = {2026},
month = oct,
doi = {10.1590/2175-8239-jbn-2026-0061en},
url = {https://europepmc.org/article/MED/42896045},
note = {CC BY},
}
RIS
TY - JOUR
TI - Effects of muscle strength training with blood flow restriction on glomerular function in people with stage 3 chronic kidney disease.
AU - Antonio Filipe Pereira Caetano
AU - Janyeliton Alencar de Oliveira
AU - Amaro Wellington da Silva
AU - Cyro Rego Cabral Junior
AU - Michelle Jacintha Oliveira Cavalcante
AU - Maria do Socorro Cirilo-Sousa
PY - 2026
DA - 2026/10/01
JO - Jornal brasileiro de nefrologia
DO - 10.1590/2175-8239-jbn-2026-0061en
UR - https://europepmc.org/article/MED/42896045
AB - Introduction Stage 3 chronic kidney disease (CKD) represents a critical juncture in clinical management. However, muscle strength training (MST) combined with blood flow restriction (BFR) has shown benefits as an adjunctive treatment, but its renal effects remain unclear.Objective To analyze the effects of MST+BFR on markers of glomerular function in individuals with CKD-3.Method A randomized, longitudinal clinical trial with 40 participants divided into 4 groups: control (G1); low-load MST (G2); high-load MST (G3); and low-load MST combined with BFR (G4). Serum creatinine, cystatin C, microalbuminuria, and estimated eGFR were used as dependent variables. The MST protocol was conducted over 12 weeks, 3 times per week, for 30-40 minutes, with 3 exercises (single- and multi-joint) per day at progressive intensities. Data analysis (intention-to-treat) was performed using the Shapiro-Wilk test (normality), paired t-test/Wilcoxon test (within-group comparisons), ANOVA/Kruskal-Wallis tests (between-group comparisons), Bonferroni test (post hoc corrections), and Cohen's d (effect size) with a p-value ≤ 0.05.Results The participants were predominantly male (52.5%) with low levels of physical activity (60%), hypertension (87.5%), and some with diabetes (37.5%). Group 4 showed a significant increase in albuminuria levels (p = 0.048), as well as significant differences compared with Group 1 (creatinine, p = 0.032) and Group 2 (creatinine, p = 0.036; and eGFR-Cr, p = 0.032).Conclusion MST+BFR was not associated with severe adverse effects on serum creatinine/cystatin C levels, eGFR estimates, or urinary creatinine and microalbuminuria levels, but it may significantly increase albuminuria levels.
SN - 0101-2800
SN - 2175-8239
ER -