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PreprintCC BYbioRxiv

Chronic Social Isolation Reshapes the Metabolome in Drosophila

  • D. Migliaccio
  • C. Spicer
  • A. D. Nguyen
  • A. Vora
  • Z. Zhang
  • W. Li1
  1. 1Texas AM University
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Abstract

Sleep, feeding, and metabolism are tightly coordinated outputs of the circadian system. Previous studies showed that chronic social isolation reduces sleep and increases feeding in Drosophila. Here, untargeted metabolomic profiling revealed that chronic social isolation induces a distinct metabolomic signature spanning amino acids, carbohydrates, and lipids, establishing a foundation for understanding the physiological consequences of social isolation.

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Cite

BibTeXRIS
BibTeX
@misc{migliaccio2026chronic,
  title = {{Chronic Social Isolation Reshapes the Metabolome in Drosophila}},
  author = {D. Migliaccio and C. Spicer and A. D. Nguyen and A. Vora and Z. Zhang and W. Li},
  howpublished = {bioRxiv},
  year = {2026},
  month = sep,
  doi = {10.64898/2026.09.24.754212},
  url = {https://www.biorxiv.org/content/10.64898/2026.09.24.754212v1},
  note = {CC BY},
}
RIS
TY  - UNPB
TI  - Chronic Social Isolation Reshapes the Metabolome in Drosophila
AU  - D. Migliaccio
AU  - C. Spicer
AU  - A. D. Nguyen
AU  - A. Vora
AU  - Z. Zhang
AU  - W. Li
PY  - 2026
DA  - 2026/09/24
PB  - bioRxiv
DO  - 10.64898/2026.09.24.754212
UR  - https://www.biorxiv.org/content/10.64898/2026.09.24.754212v1
AB  - Sleep, feeding, and metabolism are tightly coordinated outputs of the circadian system. Previous studies showed that chronic social isolation reduces sleep and increases feeding in Drosophila. Here, untargeted metabolomic profiling revealed that chronic social isolation induces a distinct metabolomic signature spanning amino acids, carbohydrates, and lipids, establishing a foundation for understanding the physiological consequences of social isolation.
ER  -