Peer-reviewedCC BYJournal for ImmunoTherapy of Cancer
542 A first-in-human phase 1/2 study of XTX501, a bispecific PD-1/masked IL-2, in metastatic non-small cell lung cancer (NSCLC)
5 affiliations
- 1Xilio Therapeutics, Inc., Waltham, MA, USA
- 21Xilio Therapeutics, Waltham, MA, USA
- 314Xilio Therapeutics, Waltham, MA, USA
- 48Xilio Therapeutics, Waltham, MA, USA
- 5Xilio Therapeutics, Waltham, Massachusetts, USA
Related
- PF chemotherapy combined with a PD-1/CTLA-4 bispecific antibody as first-line treatment in patients with recurrent/metastatic head and neck squamous cell carcinoma: a prospective, single-arm, phase II clinical study
- EMB-01, an Anti-EGFR/c-MET Bispecific Antibody, in Patients with Heavily Pretreated Metastatic Colorectal Cancer from a Phase Ib/II, Open-Label, Multicenter Study
- Cost-effectiveness of adding enzalutamide vs standard non-steroidal antiandrogen drugs for patients with metastatic hormone-sensitive prostate cancer undergoing standard first-line therapy: a within-trial, secondary end-point analysis of the ENZAMET phase 3, international randomized trial (ANZUP 1304)
- Nanoparticle polymeric micellar paclitaxel (pm-Pac), platinum, and sintilimab as first-line treatment for advanced or metastatic non-squamous non-small cell lung cancer: a phase II study
- The conformation-selective PI3Kδ inhibitor roginolisib in patients with advanced or metastatic cancer, including metastatic uveal melanoma: first-in-human clinical trial
BibTeX
@article{fantini2026firstinhuman,
title = {{542 A first-in-human phase 1/2 study of XTX501, a bispecific PD-1/masked IL-2, in metastatic non-small cell lung cancer (NSCLC)}},
author = {Damiano Fantini and Scott Coleman and Ekta Patel and Meghan Duncan and Martin Huber and Benjamin Nicholson and David Crowe and Scott McConnell and Patricia Bernardo and Myra W Popejoy and Carl Uli Bialucha},
journal = {Journal for ImmunoTherapy of Cancer},
year = {2026},
month = nov,
doi = {10.1136/jitc-2026-sitc2026.0542},
url = {https://doi.org/10.1136/jitc-2026-sitc2026.0542},
note = {CC BY},
}
RIS
TY - JOUR
TI - 542 A first-in-human phase 1/2 study of XTX501, a bispecific PD-1/masked IL-2, in metastatic non-small cell lung cancer (NSCLC)
AU - Damiano Fantini
AU - Scott Coleman
AU - Ekta Patel
AU - Meghan Duncan
AU - Martin Huber
AU - Benjamin Nicholson
AU - David Crowe
AU - Scott McConnell
AU - Patricia Bernardo
AU - Myra W Popejoy
AU - Carl Uli Bialucha
PY - 2026
DA - 2026/11/08
JO - Journal for ImmunoTherapy of Cancer
DO - 10.1136/jitc-2026-sitc2026.0542
UR - https://doi.org/10.1136/jitc-2026-sitc2026.0542
SN - 2051-1426
ER -