Remodeling of Oncogene-Related Molecular Networks Following Bariatric Surgery: a Multi-Omics Study
4 affiliations
- 1Qatar University, Doha, Qatar
- 2Doha, Qatar
- 3COMSATS University Islamabad, Islamabad, Pakistan
- 4Hamad Medical Cooperation, Doha, Qatar
Abstract
Obesity is a well-established risk factor for multiple cancers, and Metabolic Bariatric Surgery (MBS) has been associated with reduced cancer incidence and mortality. However, the molecular mechanisms underlying this risk reduction remain incompletely understood. Many recent transcriptomic, proteomic, and metabolomic studies have enabled system-wide molecular profiling following MBS. We performed a systematic analysis of publicly available MBS-related omics datasets, including transcriptomic (n = 22), proteomic (n = 6), and metabolomic studies (n = 5), with pre- and post-operative comparisons. Comparative molecular analyses across all omics datasets were performed using Ingenuity Pathway Analysis (IPA). Sustained suppression of key oncogenic pathways, including Molecular Mechanisms of Cancer, Role of Tissue Factor in Cancer, and metastasis-associated signaling, was observed in tissue transcriptomic datasets (adipose, skeletal muscle, and gastrointestinal tract). In contrast, transcriptomic datasets predominantly showed immune remodeling, characterized by activation of innate immune pathways. Key molecular markers, including CCL2, EGFL6, and S100A8, were identified as consistently regulated across multiple datasets. Proteomic analyses revealed early postoperative suppression of inflammatory and acute-phase proteins, progressive downregulation of complement and coagulation cascades, and sustained upregulation of endocrine regulators such as sex hormone-binding globulin and extracellular matrix–stabilizing factors. Metabolomic profiling demonstrated significant alterations in amino acid, bile acid, and lipid metabolism following MBS. These molecular changes collectively reflect a shift toward a less inflammatory, hormonally balanced, and metabolically favorable systemic environment. These findings highlight the impact of MBS in inhibiting cancer-promoting biological processes and identify candidate molecular biomarkers for future translational and oncologic research.
Supplementary Information: The online version contains supplementary material available at https://doi.org/10.1007/s11695-026-08959-w.
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BibTeX
@article{salhi2026remodeling,
title = {{Remodeling of Oncogene-Related Molecular Networks Following Bariatric Surgery: a Multi-Omics Study}},
author = {Mohammed Salhi and Sarah Al-Shahabi and Summaiya Khatoon and Aaiza Asif and Marwa Naeem and Muhammad Enamul Hoque Chowdhury and Shona Pedersen and Fakhar Shahid and Muhammad Jawad Khan and Zumin Shi and Aisha Naeem},
journal = {Obesity Surgery},
year = {2026},
month = oct,
doi = {10.1007/s11695-026-08959-w},
url = {https://doi.org/10.1007/s11695-026-08959-w},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Remodeling of Oncogene-Related Molecular Networks Following Bariatric Surgery: a Multi-Omics Study
AU - Mohammed Salhi
AU - Sarah Al-Shahabi
AU - Summaiya Khatoon
AU - Aaiza Asif
AU - Marwa Naeem
AU - Muhammad Enamul Hoque Chowdhury
AU - Shona Pedersen
AU - Fakhar Shahid
AU - Muhammad Jawad Khan
AU - Zumin Shi
AU - Aisha Naeem
PY - 2026
DA - 2026/10/05
JO - Obesity Surgery
DO - 10.1007/s11695-026-08959-w
UR - https://doi.org/10.1007/s11695-026-08959-w
AB - Obesity is a well-established risk factor for multiple cancers, and Metabolic Bariatric Surgery (MBS) has been associated with reduced cancer incidence and mortality. However, the molecular mechanisms underlying this risk reduction remain incompletely understood. Many recent transcriptomic, proteomic, and metabolomic studies have enabled system-wide molecular profiling following MBS. We performed a systematic analysis of publicly available MBS-related omics datasets, including transcriptomic (n = 22), proteomic (n = 6), and metabolomic studies (n = 5), with pre- and post-operative comparisons. Comparative molecular analyses across all omics datasets were performed using Ingenuity Pathway Analysis (IPA). Sustained suppression of key oncogenic pathways, including Molecular Mechanisms of Cancer, Role of Tissue Factor in Cancer, and metastasis-associated signaling, was observed in tissue transcriptomic datasets (adipose, skeletal muscle, and gastrointestinal tract). In contrast, transcriptomic datasets predominantly showed immune remodeling, characterized by activation of innate immune pathways. Key molecular markers, including CCL2, EGFL6, and S100A8, were identified as consistently regulated across multiple datasets. Proteomic analyses revealed early postoperative suppression of inflammatory and acute-phase proteins, progressive downregulation of complement and coagulation cascades, and sustained upregulation of endocrine regulators such as sex hormone-binding globulin and extracellular matrix–stabilizing factors. Metabolomic profiling demonstrated significant alterations in amino acid, bile acid, and lipid metabolism following MBS. These molecular changes collectively reflect a shift toward a less inflammatory, hormonally balanced, and metabolically favorable systemic environment. These findings highlight the impact of MBS in inhibiting cancer-promoting biological processes and identify candidate molecular biomarkers for future translational and oncologic research. Supplementary Information: The online version contains supplementary material available at https://doi.org/10.1007/s11695-026-08959-w.
SN - 0960-8923
SN - 1708-0428
ER -