The TyG-WHtR index as a novel predictor of nocturnal hypertension in metabolic syndrome
- 1Department of Cardiology, The Third Affiliated Hospital of Chongqing Medical University
Abstract
Objective: To investigate the association between triglyceride-glucose index to waist-to-height ratio (TyG-WHtR) and nocturnal hypertension in metabolic syndrome (MetS) patients.
Methods: This cross-sectional study included 180 adults with MetS undergoing 24-hour ambulatory blood pressure monitoring. Nocturnal hypertension was defined as mean nighttime SBP ≥120 mmHg and/or DBP ≥70 mmHg. Multivariable logistic regression and ROC analysis were performed.
Results: Nocturnal hypertension was present in 48.3% of participants. TyG-WHtR was significantly higher in the nocturnal hypertension group (5.7 ± 0.5 vs. 5.1 ± 0.4, p = 6.05×10 ⁻¹³ ). After adjustment for confounders, TyG-WHtR remained independently associated with nocturnal hypertension (OR: 17.27, 95% CI: 5.76–58.87, p = 1.35×10 ⁻⁶ ). The AUC was 0.794 (95% CI: 0.73–0.86), with optimal cutoff 5.65 (sensitivity 56.3%, specificity 91.4%).
Conclusions: TyG-WHtR was independently associated with nocturnal hypertension in MetS patients and showed acceptable discriminative ability, significantly better than the TyG index alone.
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BibTeX
@article{li2026tygwhtr,
title = {{The TyG-WHtR index as a novel predictor of nocturnal hypertension in metabolic syndrome}},
author = {Yanqiu Li and Hailong Su and Duan Wang and Xinlian Duan and Qin Zhang},
journal = {Frontiers in Cardiovascular Medicine},
year = {2026},
month = nov,
doi = {10.3389/fcvm.2026.1941261},
url = {https://www.frontiersin.org/articles/10.3389/fcvm.2026.1941261/full},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - The TyG-WHtR index as a novel predictor of nocturnal hypertension in metabolic syndrome
AU - Yanqiu Li
AU - Hailong Su
AU - Duan Wang
AU - Xinlian Duan
AU - Qin Zhang
PY - 2026
DA - 2026/11/03
JO - Frontiers in Cardiovascular Medicine
DO - 10.3389/fcvm.2026.1941261
UR - https://www.frontiersin.org/articles/10.3389/fcvm.2026.1941261/full
AB - Objective: To investigate the association between triglyceride-glucose index to waist-to-height ratio (TyG-WHtR) and nocturnal hypertension in metabolic syndrome (MetS) patients. Methods: This cross-sectional study included 180 adults with MetS undergoing 24-hour ambulatory blood pressure monitoring. Nocturnal hypertension was defined as mean nighttime SBP ≥120 mmHg and/or DBP ≥70 mmHg. Multivariable logistic regression and ROC analysis were performed. Results: Nocturnal hypertension was present in 48.3% of participants. TyG-WHtR was significantly higher in the nocturnal hypertension group (5.7 ± 0.5 vs. 5.1 ± 0.4, p = 6.05×10 ⁻¹³ ). After adjustment for confounders, TyG-WHtR remained independently associated with nocturnal hypertension (OR: 17.27, 95% CI: 5.76–58.87, p = 1.35×10 ⁻⁶ ). The AUC was 0.794 (95% CI: 0.73–0.86), with optimal cutoff 5.65 (sensitivity 56.3%, specificity 91.4%). Conclusions: TyG-WHtR was independently associated with nocturnal hypertension in MetS patients and showed acceptable discriminative ability, significantly better than the TyG index alone.
SN - 2297-055X
ER -