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Peer-reviewedCC BY-NC-NDInternal Medicine

Endoscopic Submucosal Dissection as a Diagnostic and Minimally Invasive Therapeutic Excision Modality for Primary Anorectal Malignant Melanoma

  • Yusaku Yokotani
  • Hiroaki Kitae
  • Kyoka Ozawa
  • Mika Mazaki
  • Hoshu Kurebayashi
  • Koki Yamamoto
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Abstract

Primary anorectal malignant melanoma is a rare mucosal malignancy with nonspecific symptoms, frequent misdiagnoses, delayed treatment, and the lack of an established standard therapeutic strategy are the reasons for a poor prognosis. Diagnostic challenges are further compounded by the low rate of preoperative histological confirmation, especially for amelanotic lesions. Given its poor prognosis, performing a less invasive resection is crucial. We herein report the case of an 82-year-old male patient who underwent endoscopic submucosal dissection as a total biopsy and was treated with immune checkpoint inhibitors as adjuvant therapy.

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Cite

BibTeXRIS
BibTeX
@article{yokotani2026endoscopic,
  title = {{Endoscopic Submucosal Dissection as a Diagnostic and Minimally Invasive Therapeutic Excision Modality for Primary Anorectal Malignant Melanoma}},
  author = {Yusaku Yokotani and Hiroaki Kitae and Kyoka Ozawa and Mika Mazaki and Hoshu Kurebayashi and Koki Yamamoto},
  journal = {Internal Medicine},
  year = {2026},
  month = oct,
  doi = {10.2169/internalmedicine.6841-25},
  url = {https://www.jstage.jst.go.jp/article/internalmedicine/65/20/65_6841-25/_article},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - Endoscopic Submucosal Dissection as a Diagnostic and Minimally Invasive Therapeutic Excision Modality for Primary Anorectal Malignant Melanoma
AU  - Yusaku Yokotani
AU  - Hiroaki Kitae
AU  - Kyoka Ozawa
AU  - Mika Mazaki
AU  - Hoshu Kurebayashi
AU  - Koki Yamamoto
PY  - 2026
DA  - 2026/10/15
JO  - Internal Medicine
DO  - 10.2169/internalmedicine.6841-25
UR  - https://www.jstage.jst.go.jp/article/internalmedicine/65/20/65_6841-25/_article
AB  - Primary anorectal malignant melanoma is a rare mucosal malignancy with nonspecific symptoms, frequent misdiagnoses, delayed treatment, and the lack of an established standard therapeutic strategy are the reasons for a poor prognosis. Diagnostic challenges are further compounded by the low rate of preoperative histological confirmation, especially for amelanotic lesions. Given its poor prognosis, performing a less invasive resection is crucial. We herein report the case of an 82-year-old male patient who underwent endoscopic submucosal dissection as a total biopsy and was treated with immune checkpoint inhibitors as adjuvant therapy.
SN  - 1349-7235
SN  - 0918-2918
ER  -