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Peer-reviewedCC BY-NC-NDProteomics. Clinical applications

Identification of Potential Biomarkers for Ulcerative Colitis and Analysis of Immune Cell Infiltration: A Study Based on Data-Independent Acquisition Proteomics and the GEO Public Database.

  • Shuai Wang1
  • Hualiang Deng1
  • Dajuan Sun1,2
  1. 1Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China.
  2. 2Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China.
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Abstract

Background

Ulcerative colitis (UC) is a challenging inflammatory bowel disease characterized by chronic inflammation of the colon's mucosal layer. Despite advances in medical research, UC lacks definitive diagnostic tests and targeted treatments.Aims

This study aimed to preliminarily explore non-invasive potential biomarkers for UC based on proteomic analysis and publicly available GEO datasets.Materials & methods

Bioinformatics analyses including ssGSEA for immune infiltration assessment, Spearman correlation analysis, ROC analysis, GSEA, and in silico drug prediction were performed.Results

Four candidate hub genes (KRT17, TCEA3, ACP5, and ACOT13) were identified. ROC analysis demonstrated their potential clinical diagnostic value, and GSEA revealed their association with inflammatory pathways. A total of 28 potential compounds targeting these biomarkers were predicted, among which cinacalcet was selected as a priority candidate drug for further research.Conclusion

The identified hub genes have the potential to act as non-invasive candidate biomarkers for the early diagnosis of UC.

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Cite

BibTeXRIS
BibTeX
@article{wang2026identification,
  title = {{Identification of Potential Biomarkers for Ulcerative Colitis and Analysis of Immune Cell Infiltration: A Study Based on Data-Independent Acquisition Proteomics and the GEO Public Database.}},
  author = {Shuai Wang and Hualiang Deng and Dajuan Sun},
  journal = {Proteomics. Clinical applications},
  year = {2026},
  month = nov,
  doi = {10.1002/prca.70061},
  url = {https://europepmc.org/article/MED/42974952},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - Identification of Potential Biomarkers for Ulcerative Colitis and Analysis of Immune Cell Infiltration: A Study Based on Data-Independent Acquisition Proteomics and the GEO Public Database.
AU  - Shuai Wang
AU  - Hualiang Deng
AU  - Dajuan Sun
PY  - 2026
DA  - 2026/11/01
JO  - Proteomics. Clinical applications
DO  - 10.1002/prca.70061
UR  - https://europepmc.org/article/MED/42974952
AB  - Background  Ulcerative colitis (UC) is a challenging inflammatory bowel disease characterized by chronic inflammation of the colon's mucosal layer. Despite advances in medical research, UC lacks definitive diagnostic tests and targeted treatments.Aims  This study aimed to preliminarily explore non-invasive potential biomarkers for UC based on proteomic analysis and publicly available GEO datasets.Materials & methods  Bioinformatics analyses including ssGSEA for immune infiltration assessment, Spearman correlation analysis, ROC analysis, GSEA, and in silico drug prediction were performed.Results  Four candidate hub genes (KRT17, TCEA3, ACP5, and ACOT13) were identified. ROC analysis demonstrated their potential clinical diagnostic value, and GSEA revealed their association with inflammatory pathways. A total of 28 potential compounds targeting these biomarkers were predicted, among which cinacalcet was selected as a priority candidate drug for further research.Conclusion  The identified hub genes have the potential to act as non-invasive candidate biomarkers for the early diagnosis of UC.
SN  - 1862-8346
SN  - 1862-8354
ER  -