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Peer-reviewedCC BYScientific Reports

Red blood cell-derived parameters as a potential tool in the differential diagnosis of parkinsonian syndromes

  • Natalia Madetko-Alster1
  • Dagmara Otto-Ślusarczyk2
  • Bartosz Migda3
  • Patryk Chunowski1
  • Marta Struga2
  • Piotr Alster1
  1. 1Department of Neurology, Medical University of Warsaw
  2. 2Department of Biochemistry, Medical University of Warsaw
  3. 3Diagnostic Ultrasound Lab, Department of Pediatric Radiology, Medical University of Warsaw
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Abstract

Atypical parkinsonian syndromes account for a small but clinically important proportion of parkinsonism cases. Compared with Parkinson’s disease (PD), these disorders are characterized by more rapid deterioration and more pronounced deficits. Progressive supranuclear palsy (PSP) is the most common form of atypical parkinsonism. Due to the overlapping clinical features of PSP and PD, there is a clear need for the development of practical supplementary diagnostic tools. The study included 30 patients with a clinical diagnosis of PD, 29 with PSP-Richardson’s Syndrome (PSP-RS), 17 with PSP-Parkinsonism Predominant (PSP-P), and 23 healthy controls. Each participant underwent blood sample analysis, including morphological evaluation. Analysis of blood parameters revealed that red cell distribution width-coefficient of variation (RDW-CV) has differential diagnostic potential. Elevated RDW-CV values were associated with PSP-RS and showed significant differences compared with all other groups. No other blood parameters demonstrated statistically significant values for differential diagnosis. The results of this study suggest that red blood cell-derived parameters may serve as useful supplementary tools for differentiating symptomatically overlapping parkinsonian syndromes. These findings highlight the importance of further research into factors affecting red blood cells in patients with parkinsonian syndromes.

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Cite

BibTeXRIS
BibTeX
@article{madetkoalster2026blood,
  title = {{Red blood cell-derived parameters as a potential tool in the differential diagnosis of parkinsonian syndromes}},
  author = {Natalia Madetko-Alster and Dagmara Otto-Ślusarczyk and Bartosz Migda and Patryk Chunowski and Marta Struga and Piotr Alster},
  journal = {Scientific Reports},
  year = {2026},
  month = jul,
  doi = {10.1038/s41598-026-62325-5},
  url = {https://doi.org/10.1038/s41598-026-62325-5},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Red blood cell-derived parameters as a potential tool in the differential diagnosis of parkinsonian syndromes
AU  - Natalia Madetko-Alster
AU  - Dagmara Otto-Ślusarczyk
AU  - Bartosz Migda
AU  - Patryk Chunowski
AU  - Marta Struga
AU  - Piotr Alster
PY  - 2026
DA  - 2026/07/01
JO  - Scientific Reports
DO  - 10.1038/s41598-026-62325-5
UR  - https://doi.org/10.1038/s41598-026-62325-5
AB  - Atypical parkinsonian syndromes account for a small but clinically important proportion of parkinsonism cases. Compared with Parkinson’s disease (PD), these disorders are characterized by more rapid deterioration and more pronounced deficits. Progressive supranuclear palsy (PSP) is the most common form of atypical parkinsonism. Due to the overlapping clinical features of PSP and PD, there is a clear need for the development of practical supplementary diagnostic tools. The study included 30 patients with a clinical diagnosis of PD, 29 with PSP-Richardson’s Syndrome (PSP-RS), 17 with PSP-Parkinsonism Predominant (PSP-P), and 23 healthy controls. Each participant underwent blood sample analysis, including morphological evaluation. Analysis of blood parameters revealed that red cell distribution width-coefficient of variation (RDW-CV) has differential diagnostic potential. Elevated RDW-CV values were associated with PSP-RS and showed significant differences compared with all other groups. No other blood parameters demonstrated statistically significant values for differential diagnosis. The results of this study suggest that red blood cell-derived parameters may serve as useful supplementary tools for differentiating symptomatically overlapping parkinsonian syndromes. These findings highlight the importance of further research into factors affecting red blood cells in patients with parkinsonian syndromes.
SN  - 2045-2322
ER  -