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Peer-reviewedCC BY-NCThe Cochrane database of systematic reviews

Antibiotic therapy for pelvic inflammatory disease: a network meta-analysis.

  • Michail Papapanou1,2
  • Melina Nikolakea2,3
  • Ismini Tsakiri2,3
  • Maria Toulaki2,3
  • Kalliopi Syristatidi2,4
  • Charalampos S Siristatidis2,5
  • Patricia Ziegelmann6
  • Jonathan Ross7,8
  • Ricardo F Savaris9
9 affiliations
  1. 1Second Department of Obstetrics and Gynecology, Aretaieio Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
  2. 2Cochrane Athens, Athens, Greece.
  3. 3School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
  4. 4School of Medicine, Dentistry and Nursing, University of Glasgow, Glasgow, Scotland, UK.
  5. 5Assisted Reproduction Unit, Second Department of Obstetrics and Gynaecology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
  6. 6Statistics, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.
  7. 7University of Birmingham, Birmingham, UK.
  8. 8Birmingham City University, Birmingham, UK.
  9. 9Ginecologia e Obstetricia, UFRGS-FAMED, Porto Alegre, Brazil.
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Abstract

Objectives

This is a protocol for a Cochrane review (intervention). The objectives are as follows: To assess the comparative benefits and harms of systemic antibiotic regimens for the treatment of acute pelvic inflammatory disease in women of reproductive age. The secondary objectives are: to estimate the incremental effect of adding nitroimidazole to an antibiotic backbone; to compare the efficacy of azithromycin-containing regimens with relevant alternatives, where the evidence network permits (in Network B, this comparison depends on setting-disaggregated data from a single eligible trial and may not be estimable); and to describe narratively whether treatment hierarchies appear consistent between the outpatient (Network A) and inpatient (Network B) evidence, since direct statistical comparison between networks is not undertaken.

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Cite

BibTeXRIS
BibTeX
@article{papapanou2026antibiotic,
  title = {{Antibiotic therapy for pelvic inflammatory disease: a network meta-analysis.}},
  author = {Michail Papapanou and Melina Nikolakea and Ismini Tsakiri and Maria Toulaki and Kalliopi Syristatidi and Charalampos S Siristatidis and Patricia Ziegelmann and Jonathan Ross and Ricardo F Savaris},
  journal = {The Cochrane database of systematic reviews},
  year = {2026},
  month = oct,
  doi = {10.1002/14651858.cd016401},
  url = {https://europepmc.org/article/MED/42905124},
  note = {CC BY-NC},
}
RIS
TY  - JOUR
TI  - Antibiotic therapy for pelvic inflammatory disease: a network meta-analysis.
AU  - Michail Papapanou
AU  - Melina Nikolakea
AU  - Ismini Tsakiri
AU  - Maria Toulaki
AU  - Kalliopi Syristatidi
AU  - Charalampos S Siristatidis
AU  - Patricia Ziegelmann
AU  - Jonathan Ross
AU  - Ricardo F Savaris
PY  - 2026
DA  - 2026/10/21
JO  - The Cochrane database of systematic reviews
DO  - 10.1002/14651858.cd016401
UR  - https://europepmc.org/article/MED/42905124
AB  - Objectives  This is a protocol for a Cochrane review (intervention). The objectives are as follows: To assess the comparative benefits and harms of systemic antibiotic regimens for the treatment of acute pelvic inflammatory disease in women of reproductive age. The secondary objectives are: to estimate the incremental effect of adding nitroimidazole to an antibiotic backbone; to compare the efficacy of azithromycin-containing regimens with relevant alternatives, where the evidence network permits (in Network B, this comparison depends on setting-disaggregated data from a single eligible trial and may not be estimable); and to describe narratively whether treatment hierarchies appear consistent between the outpatient (Network A) and inpatient (Network B) evidence, since direct statistical comparison between networks is not undertaken.
SN  - 1469-493X
ER  -