Homoisoflavanones, Alkaloid, and Norsesquiterpenoid from Polygonatum cyrtonema and Their Immunomodulatory Effects
5 affiliations
- 1Anhui University of Chinese Medicine , ,
- 2Guoyang County Hospital of Traditional Chinese Medicine , ,
- 3Anhui Medical University , , ,
- 4Anhui Province Key Laboratory of Bioactive Natural Products , ,
- 5Anhui Province Key Laboratory of New Manufacturing Technology for Traditional Chinese Medicine Decoction Pieces , ,
Abstract
Polygonatum cyrtonema (Huang jing) is widely used in both the food and traditional Chinese medicine industries. A chemical investigation of the rhizome of cultivated P. cyrtonema yielded six previously undescribed compounds─one norsesquiterpenoid (1), one pyridine alkaloid (2), and four homoisoflavanones (3a, 4a, 5a, 6a)─together with 9 known compounds (3b, 4b, 5b, 6b, 7–11). Their structures were established on the basis of extensive spectroscopic data and quantum chemical calculations, including NMR, HRESIMS, and calculated ECD. The enantiomers of the C-6-methylated homoisoflavanones (3a/3b–6a/6b) were successfully isolated via chiral HPLC. All compounds were evaluated for their immunomodulatory activity using RAW264.7 macrophages at concentrations ranging from 3.125 to 25 μM. Only compounds 8 and 11 enhanced the proliferation and phagocytosis of RAW264.7 macrophages and upregulated the secretion of NO, IL-6, and TNF-α.
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BibTeX
@article{zhao2026homoisoflavanones,
title = {{Homoisoflavanones, Alkaloid, and Norsesquiterpenoid from Polygonatum cyrtonema and Their Immunomodulatory Effects}},
author = {Hongsu Zhao and Caixia Lu and Fucai Ren and Xiaoxiao Wei and Tongsheng Wang and Wuxi Zhou and Deling Wu and Fengqing Xu and Renzhong Wang},
journal = {ACS omega},
year = {2026},
month = sep,
doi = {10.1021/acsomega.6c06988},
url = {https://europepmc.org/article/PMC/PMC13670285},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Homoisoflavanones, Alkaloid, and Norsesquiterpenoid from Polygonatum cyrtonema and Their Immunomodulatory Effects
AU - Hongsu Zhao
AU - Caixia Lu
AU - Fucai Ren
AU - Xiaoxiao Wei
AU - Tongsheng Wang
AU - Wuxi Zhou
AU - Deling Wu
AU - Fengqing Xu
AU - Renzhong Wang
PY - 2026
DA - 2026/09/30
JO - ACS omega
DO - 10.1021/acsomega.6c06988
UR - https://europepmc.org/article/PMC/PMC13670285
AB - Polygonatum cyrtonema (Huang jing) is widely used in both the food and traditional Chinese medicine industries. A chemical investigation of the rhizome of cultivated P. cyrtonema yielded six previously undescribed compounds─one norsesquiterpenoid (1), one pyridine alkaloid (2), and four homoisoflavanones (3a, 4a, 5a, 6a)─together with 9 known compounds (3b, 4b, 5b, 6b, 7–11). Their structures were established on the basis of extensive spectroscopic data and quantum chemical calculations, including NMR, HRESIMS, and calculated ECD. The enantiomers of the C-6-methylated homoisoflavanones (3a/3b–6a/6b) were successfully isolated via chiral HPLC. All compounds were evaluated for their immunomodulatory activity using RAW264.7 macrophages at concentrations ranging from 3.125 to 25 μM. Only compounds 8 and 11 enhanced the proliferation and phagocytosis of RAW264.7 macrophages and upregulated the secretion of NO, IL-6, and TNF-α.
SN - 2470-1343
ER -