Skip to content
DraconiticResearch
Search Sources API
203,234 studies31 sourcesUpdated 34 min ago
Peer-reviewedCC BYJournal of neuro-oncology

Incidence of intra-axial brain metastases in Eastern Finland.

  • Samir Moniruzzaman1,2,3,4
  • Susanna Rantala5
  • Juhana Hakumäki6,7
  • Tuomas Rauramaa8
8 affiliations
  1. 1Department of Neurosurgery, Kuopio University Hospital and Neurosurgery, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland. [email protected].
  2. 2Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland. [email protected].
  3. 3Department of Clinical Radiology, Diagnostic Imaging Center, Kuopio University Hospital, Kuopio, Finland. [email protected].
  4. 4Department of Clinical Pathology, Kuopio University Hospital and Clinical Pathology and Forensic Medicine, Institute of Clinical Medicine, University of Eastern Finland, P.O. Box 1627, Kuopio, 70211, Finland. [email protected].
  5. 5Department of Neurosurgery, Kuopio University Hospital and Neurosurgery, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.
  6. 6Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.
  7. 7Department of Clinical Radiology, Diagnostic Imaging Center, Kuopio University Hospital, Kuopio, Finland.
  8. 8Department of Clinical Pathology, Kuopio University Hospital and Clinical Pathology and Forensic Medicine, Institute of Clinical Medicine, University of Eastern Finland, P.O. Box 1627, Kuopio, 70211, Finland.
Read full textPDFDOICite

Abstract

Purpose

Brain metastases (BM) incidence and characteristics remain poorly defined due to registry data being often incomplete, recording only primary tumors or unspecified metastases. The objective of this study was to examine BM incidence rates and characteristics confirmed by MRI in North Savo, Finland.Methods

In this retrospective study, North Savo residents with first MRI diagnosis of BM between 1 January 2004 and 31 December 2023 were identified through the radiology information system, irrespective of primary cancer diagnosis date. Medical and histopathological records were reviewed. Population person-years were estimated by summing annual end-year counts of all North Savo residents obtained from Statistics Finland. Crude incidence rates and age-standardized incidence rates (ASIRs), standardized to the 2013 European Standard population, were calculated. Temporal trends were assessed using age-adjusted Poisson regression.Results

Among 516 patients, 474 had histopathological verification. Cancers originating from lung and breast tissue accounted for 56.8% of BM cases. Overall crude incidence was 10.22 (95% CI 9.36-11.15) and ASIR was 9.20 (95% CI 8.42-10.04) per 100,000 person years. ASIR increased from 5.8 in 2004-2008 to 11.8 in 2019-2023. Age-adjusted Poisson regression estimated a 24% increase in incidence per five-year period (incidence rate ratio 1.24; 95% CI 1.14-1.34; P < 0.001). Age-specific incidence peaked at 33.1 per 100,000 person years among patients aged 70-74 years.Conclusions

MRI-confirmed BM incidence increased over 20 years, despite age standardization. Incidence was highest among older adults. These findings provide contemporary population-based epidemiological data of BM incidence.

Related

  1. The Incidence and Diagnosis of Intra-articular Extension With Spiral Distal Third Humerus Fractures
    Journal of the American Academy of Orthopaedic Surgeons. Global research & reviewsPeer-reviewedCC BY-NC-NDFull textSurgery & anaesthesiaEurope PMC
  2. Complete Response to First-Line Trastuzumab Deruxtecan in Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Extra-axial Central Nervous System Metastases.
    Maria João Oura, Rita Pinho, Fernando Osório +2
    CureusPeer-reviewedCC BYFull textGeneral medicineEurope PMC
  3. Estimated incidence and number of new cases with prenatal alcohol exposure and fetal alcohol spectrum disorders in Finland 1990–2025
    Mirjami Jolma, Mikko Koivu-Jolma, Mika Gissler +2
    PLOS OnePeer-reviewedCC BYFull textEpidemiology & public healthNutritionPLOSEurope PMC
  4. Opposing trends in early-onset dementia incidence across subtypes in Finland, 2016–2024
    J Pöyhönen, J Reinikainen, E Lindell +4
    The European Journal of Public HealthPeer-reviewedCC BY-NC 4.0Full textPsychiatry & mental healthPMCEurope PMC
  5. Educational inequalities in incidence and mortality trends of four common cancers in Finland
    AF Mäenpää, EM Mäkinen, SH Lappi-Heikkinen +5
    The European Journal of Public HealthPeer-reviewedCC BY-NC 4.0Full textOncologyPMCEurope PMC

Cite

BibTeXRIS
BibTeX
@article{moniruzzaman2026incidence,
  title = {{Incidence of intra-axial brain metastases in Eastern Finland.}},
  author = {Samir Moniruzzaman and Susanna Rantala and Juhana Hakumäki and Tuomas Rauramaa},
  journal = {Journal of neuro-oncology},
  year = {2026},
  month = oct,
  doi = {10.1007/s11060-026-05842-7},
  url = {https://europepmc.org/article/MED/42900244},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Incidence of intra-axial brain metastases in Eastern Finland.
AU  - Samir Moniruzzaman
AU  - Susanna Rantala
AU  - Juhana Hakumäki
AU  - Tuomas Rauramaa
PY  - 2026
DA  - 2026/10/20
JO  - Journal of neuro-oncology
DO  - 10.1007/s11060-026-05842-7
UR  - https://europepmc.org/article/MED/42900244
AB  - Purpose  Brain metastases (BM) incidence and characteristics remain poorly defined due to registry data being often incomplete, recording only primary tumors or unspecified metastases. The objective of this study was to examine BM incidence rates and characteristics confirmed by MRI in North Savo, Finland.Methods  In this retrospective study, North Savo residents with first MRI diagnosis of BM between 1 January 2004 and 31 December 2023 were identified through the radiology information system, irrespective of primary cancer diagnosis date. Medical and histopathological records were reviewed. Population person-years were estimated by summing annual end-year counts of all North Savo residents obtained from Statistics Finland. Crude incidence rates and age-standardized incidence rates (ASIRs), standardized to the 2013 European Standard population, were calculated. Temporal trends were assessed using age-adjusted Poisson regression.Results  Among 516 patients, 474 had histopathological verification. Cancers originating from lung and breast tissue accounted for 56.8% of BM cases. Overall crude incidence was 10.22 (95% CI 9.36-11.15) and ASIR was 9.20 (95% CI 8.42-10.04) per 100,000 person years. ASIR increased from 5.8 in 2004-2008 to 11.8 in 2019-2023. Age-adjusted Poisson regression estimated a 24% increase in incidence per five-year period (incidence rate ratio 1.24; 95% CI 1.14-1.34; P < 0.001). Age-specific incidence peaked at 33.1 per 100,000 person years among patients aged 70-74 years.Conclusions  MRI-confirmed BM incidence increased over 20 years, despite age standardization. Incidence was highest among older adults. These findings provide contemporary population-based epidemiological data of BM incidence.
SN  - 0167-594X
SN  - 1573-7373
ER  -