Induction Systemic Therapy Followed by Response-Adapted Consolidative Radiation in Locally Advanced Non-Melanoma Skin Cancer: A Retrospective Case Series.
6 affiliations
- 1Chao Family Comprehensive Cancer Center, University of California, Orange, CA 92868, USA.
- 2Division of Medical Oncology, Moores Cancer Center, University of California, San Diego, CA 92037, USA.
- 3Department of Otolaryngology-Head and Neck Surgery, Indiana University Health, Indianopolis, IN 46202, USA.
- 4Department of Radiation Medicine and Applied Sciences, University of California, San Diego, CA 92037, USA.
- 5Department of Radiology, University of California, San Diego, CA 92037, USA.
- 6Department of Otolaryngology-Head and Neck Surgery, University of California, San Diego, CA 92037, USA.
Abstract
Background
There exists an unmet clinical need to define definitive management strategies for patients with locally advanced non-melanoma skin cancers (NMSC), particularly if not amenable to surgical resection.Methods
We retrospectively reviewed a case series of locally advanced unresectable NMSC treated with induction systemic treatment followed by response-adapted consolidative radiation.Results
We identified 15 patients who met study criteria, including seven with basal cell carcinoma (BCC), six with cutaneous squamous cell carcinoma (CSCC), and two with Merkel cell carcinoma (MCC). Clinical complete response (CR) by physical examination was observed in all 15 patients. No locoregional or distant recurrences were observed in any histologic subtype after completion of radiation (median follow-up from completion of radiation: 18.1 months BCC, 22.5 months CSCC, 22.7 months MCC). The median duration of observed response (DOOR), measured from first clinical response was 26.9 months (26.2 BCC, 29.4 CSCC, 27.1 MCC). Radiation treatment volumes were response-adapted with median gross tumor volume reduction of 55.3% (15.3%-100%). Median treatment-free response was 20.5 months. No unexpected systemic therapy related toxicities were identified.Conclusions
In this single-institution retrospective case series, induction systemic therapy followed by response-adapted consolidative radiation was feasible and associated with durable disease control in selected patients with locally advanced unresectable NMSC.
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BibTeX
@article{vaidya2026induction,
title = {{Induction Systemic Therapy Followed by Response-Adapted Consolidative Radiation in Locally Advanced Non-Melanoma Skin Cancer: A Retrospective Case Series.}},
author = {Poorva Vaidya and Tali Azenkot and John Bliamptis and Mitchell Toby Victor and Anna Dornisch and Jennifer Chang and Parag Sanghvi and Theresa Guo and Soo J Park},
journal = {Current oncology (Toronto, Ont.)},
year = {2026},
month = oct,
doi = {10.3390/curroncol33100602},
url = {https://europepmc.org/article/MED/42930169},
note = {CC BY},
}
RIS
TY - JOUR
TI - Induction Systemic Therapy Followed by Response-Adapted Consolidative Radiation in Locally Advanced Non-Melanoma Skin Cancer: A Retrospective Case Series.
AU - Poorva Vaidya
AU - Tali Azenkot
AU - John Bliamptis
AU - Mitchell Toby Victor
AU - Anna Dornisch
AU - Jennifer Chang
AU - Parag Sanghvi
AU - Theresa Guo
AU - Soo J Park
PY - 2026
DA - 2026/10/06
JO - Current oncology (Toronto, Ont.)
DO - 10.3390/curroncol33100602
UR - https://europepmc.org/article/MED/42930169
AB - Background There exists an unmet clinical need to define definitive management strategies for patients with locally advanced non-melanoma skin cancers (NMSC), particularly if not amenable to surgical resection.Methods We retrospectively reviewed a case series of locally advanced unresectable NMSC treated with induction systemic treatment followed by response-adapted consolidative radiation.Results We identified 15 patients who met study criteria, including seven with basal cell carcinoma (BCC), six with cutaneous squamous cell carcinoma (CSCC), and two with Merkel cell carcinoma (MCC). Clinical complete response (CR) by physical examination was observed in all 15 patients. No locoregional or distant recurrences were observed in any histologic subtype after completion of radiation (median follow-up from completion of radiation: 18.1 months BCC, 22.5 months CSCC, 22.7 months MCC). The median duration of observed response (DOOR), measured from first clinical response was 26.9 months (26.2 BCC, 29.4 CSCC, 27.1 MCC). Radiation treatment volumes were response-adapted with median gross tumor volume reduction of 55.3% (15.3%-100%). Median treatment-free response was 20.5 months. No unexpected systemic therapy related toxicities were identified.Conclusions In this single-institution retrospective case series, induction systemic therapy followed by response-adapted consolidative radiation was feasible and associated with durable disease control in selected patients with locally advanced unresectable NMSC.
SN - 1198-0052
SN - 1718-7729
ER -