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Peer-reviewedCC BY-NC-ND 4.0Poultry Science

Phosphatidic acid acts as a signaling lipid to direct glycerolipid versus glycerophospholipid flux in chicken muscle

  • Hongtai Li1,2
  • Jiyu Jia1,2
  • Jingqi Shen1,2
  • Yaqi Dai1,2
  • Botong Chen1,2
  • Wei Wang2
  • Yujie Guo2
  • Yadong Tian2
  • Xiangtao Kang1,2
  • Guoxi Li1,2
  1. 1The Shennong Laboratory, Henan Agricultural University, Zhengzhou, Henan, 450046, China
  2. 2Henan Engineering Technology Research Center for Poultry Breeding, Henan Agricultural University, Zhengzhou, Henan, 450046, China
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Abstract

Chicken is the fastest-growing animal protein source globally. However, long-term directional selection has created significant quality differences between fast-growing broilers and indigenous breeds, with the latter exhibiting superior lipid composition and flavor, though the underlying metabolic mechanisms remain unclear. This study integrated lipidomics, metabolomics, and transcriptomics to systematically characterize lipid deposition in breast muscle of fast-growing Arbor Acres broilers versus indigenous Gushi chickens, identifying the 3-phosphoglycerate (3-PGA)/glycerol-3-phosphate (G3P)/phosphatidic acid (PA) axis as a core metabolic node. Functional validation revealed PA acts as a key signaling lipid, regulating breed-specific lipid composition through PLPP1 (glycerolipid pathway) and CDS2 (glycerophospholipid pathway). In ovo PA supplementation at embryonic day 17 activated PPAR signaling and promoted lipid droplet formation and triglyceride deposition without affecting growth performance. These findings establish PA-mediated metabolic partitioning as a molecular switch for breed-specific lipid composition, providing novel insights into meat quality regulation and molecular targets for breeding superior chicken.

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Cite

BibTeXRIS
BibTeX
@article{li2026phosphatidic,
  title = {{Phosphatidic acid acts as a signaling lipid to direct glycerolipid versus glycerophospholipid flux in chicken muscle}},
  author = {Hongtai Li and Jiyu Jia and Jingqi Shen and Yaqi Dai and Botong Chen and Wei Wang and Yujie Guo and Yadong Tian and Xiangtao Kang and Guoxi Li},
  journal = {Poultry Science},
  year = {2026},
  month = oct,
  doi = {10.1016/j.psj.2026.107989},
  url = {https://doi.org/10.1016/j.psj.2026.107989},
  note = {CC BY-NC-ND 4.0},
}
RIS
TY  - JOUR
TI  - Phosphatidic acid acts as a signaling lipid to direct glycerolipid versus glycerophospholipid flux in chicken muscle
AU  - Hongtai Li
AU  - Jiyu Jia
AU  - Jingqi Shen
AU  - Yaqi Dai
AU  - Botong Chen
AU  - Wei Wang
AU  - Yujie Guo
AU  - Yadong Tian
AU  - Xiangtao Kang
AU  - Guoxi Li
PY  - 2026
DA  - 2026/10/17
JO  - Poultry Science
DO  - 10.1016/j.psj.2026.107989
UR  - https://doi.org/10.1016/j.psj.2026.107989
AB  - Chicken is the fastest-growing animal protein source globally. However, long-term directional selection has created significant quality differences between fast-growing broilers and indigenous breeds, with the latter exhibiting superior lipid composition and flavor, though the underlying metabolic mechanisms remain unclear. This study integrated lipidomics, metabolomics, and transcriptomics to systematically characterize lipid deposition in breast muscle of fast-growing Arbor Acres broilers versus indigenous Gushi chickens, identifying the 3-phosphoglycerate (3-PGA)/glycerol-3-phosphate (G3P)/phosphatidic acid (PA) axis as a core metabolic node. Functional validation revealed PA acts as a key signaling lipid, regulating breed-specific lipid composition through PLPP1 (glycerolipid pathway) and CDS2 (glycerophospholipid pathway). In ovo PA supplementation at embryonic day 17 activated PPAR signaling and promoted lipid droplet formation and triglyceride deposition without affecting growth performance. These findings establish PA-mediated metabolic partitioning as a molecular switch for breed-specific lipid composition, providing novel insights into meat quality regulation and molecular targets for breeding superior chicken.
SN  - 0032-5791
SN  - 1525-3171
ER  -