TOMM5 is associated with oral cancer progression: a multi-omics analysis from single-cell atlas to in vitro validation.
4 affiliations
- 1Department of Pathology, The First Affiliated Hospital of Guangxi Medical University, Nanning, PR China.
- 2Department of General Practice, Guangxi Medical University, Nanning, PR China.
- 3Department of Human Anatomy, College of Basic Medicine, Guangxi Medical University, Nanning, PR China.
- 4Department of Stomatology, The First Affiliated Hospital of Guangxi Medical University, Nanning, PR China.
Abstract
Aims
Translocase of Outer Mitochondrial Membrane 5 (TOMM5), a mitochondrial outer membrane translocase subunit implicated in tumorigenesis, remains unexplored in oral cancer. Herein, we aimed to decipher the role of TOMM5 in oral cancer.Methods
This study comprehensively explored the expression profile, clinical significance, and functional roles of TOMM5 in oral carcinogenesis with global RNA-seq and microarray datasets. In vitro experiments were performed for evaluating the impact of TOMM5 knockdown on the biological functions of oral cancer cells. Distribution heterogeneity of TOMM5 expression and related cellular trajectory was analyzed through scRNA-seq. The therapeutic implications of TOMM5 for oral cancer were analyzed through drug sensitivity prediction and tumor immune dysfunction and exclusion (TIDE) scoring.Results
TOMM5 was significantly overexpressed in oral cancer tissues and demonstrated moderate diagnostic accuracy. TOMM5 knockdown significantly suppressed aggressive biological behaviors of oral cancer cells. ScRNA-seq data revealed predominant TOMM5 expression in B cells, decreasing with differentiation, and linked distinct pathway activities to specific cellular compartments. High TOMM5 expression was linked to reduced immune cell infiltration and sensitivity to Paclitaxel/Vincristine.Conclusions
Overexpressed TOMM5 shows potential as a biomarker in oral cancer, correlating with tumor progression and immune infiltration.
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BibTeX
@article{gao2026tomm5,
title = {{TOMM5 is associated with oral cancer progression: a multi-omics analysis from single-cell atlas to in vitro validation.}},
author = {Li Gao and Jian-Di Li and Yi-Yang Chen and Ge-Li Tan and Jian-Jia Zeng and Xi Lin and Lu Liang and Shuang Xia and Guo-Jiao Wu and Gang Chen},
journal = {Future science OA},
year = {2026},
month = oct,
doi = {10.1080/20565623.2026.2741252},
url = {https://europepmc.org/article/MED/42866938},
note = {CC BY-NC},
}
RIS
TY - JOUR
TI - TOMM5 is associated with oral cancer progression: a multi-omics analysis from single-cell atlas to in vitro validation.
AU - Li Gao
AU - Jian-Di Li
AU - Yi-Yang Chen
AU - Ge-Li Tan
AU - Jian-Jia Zeng
AU - Xi Lin
AU - Lu Liang
AU - Shuang Xia
AU - Guo-Jiao Wu
AU - Gang Chen
PY - 2026
DA - 2026/10/13
JO - Future science OA
DO - 10.1080/20565623.2026.2741252
UR - https://europepmc.org/article/MED/42866938
AB - Aims Translocase of Outer Mitochondrial Membrane 5 (TOMM5), a mitochondrial outer membrane translocase subunit implicated in tumorigenesis, remains unexplored in oral cancer. Herein, we aimed to decipher the role of TOMM5 in oral cancer.Methods This study comprehensively explored the expression profile, clinical significance, and functional roles of TOMM5 in oral carcinogenesis with global RNA-seq and microarray datasets. In vitro experiments were performed for evaluating the impact of TOMM5 knockdown on the biological functions of oral cancer cells. Distribution heterogeneity of TOMM5 expression and related cellular trajectory was analyzed through scRNA-seq. The therapeutic implications of TOMM5 for oral cancer were analyzed through drug sensitivity prediction and tumor immune dysfunction and exclusion (TIDE) scoring.Results TOMM5 was significantly overexpressed in oral cancer tissues and demonstrated moderate diagnostic accuracy. TOMM5 knockdown significantly suppressed aggressive biological behaviors of oral cancer cells. ScRNA-seq data revealed predominant TOMM5 expression in B cells, decreasing with differentiation, and linked distinct pathway activities to specific cellular compartments. High TOMM5 expression was linked to reduced immune cell infiltration and sensitivity to Paclitaxel/Vincristine.Conclusions Overexpressed TOMM5 shows potential as a biomarker in oral cancer, correlating with tumor progression and immune infiltration.
SN - 2056-5623
ER -