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Peer-reviewedCC BY 4.0Journal of Molecular and Cellular Cardiology Plus

Myocardial lipid remodeling in patients with myocardial infarction undergoing cardiac surgery

  • Tomoyuki Shiozawa1
  • Tomoyasu Kadoguchi2,3
  • Hyeon-Cheol Lee-Okada4
  • Kazunori Shimada5
  • Satoshi Matsushita6
  • Takehiko Yokomizo4
  • Tetsuro Miyazaki5,7
  • Tatsuro Aikawa5
  • Hidemori Hayashi5
  • Satoru Suwa1
  • Atsushi Amano6
  • Yuji Nakazato5
6 more authors
  • Hiroyuki Daida8
  • Minoru Tabata6
  • Naoshi Fukui2,9
  • Nobuho Tanaka9
  • Hirotaka Tsuno9
  • Tohru Minamino5
9 affiliations
  1. 1Department of Cardiovascular Medicine, Juntendo University Shizuoka Hospital, Shizuoka, Japan
  2. 2Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Tokyo, Japan
  3. 3Sportology Center, Juntendo University Graduate School of Medicine, Tokyo, Japan
  4. 4Department of Biochemistry, Juntendo University Graduate School of Medicine, Tokyo, Japan
  5. 5Department of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan
  6. 6Department of Cardiovascular Surgery, Juntendo University Graduate School of Medicine, Tokyo, Japan
  7. 7Laboratory of Bioregulatory Clinical Pharmacology, Faculty of Pharmacy, Juntendo University, Chiba, Japan
  8. 8Faculty of Health Science, Juntendo University, Tokyo, Japan
  9. 9Clinical Research Center, National Hospital Organization Sagamihara National Hospital, Sagamihara, Japan
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Abstract

Myocardial lipid remodeling in myocardial infarction (MI) remains insufficiently characterized in human myocardium. Using liquid chromatography–mass spectrometry, we analyzed left atrial appendage tissue from patients with and without MI undergoing cardiac surgery. MI was characterized by reduced phospholipid species containing omega-3 polyunsaturated fatty acids (PUFAs) and myristic acid, together with reduced diacylglycerol species containing omega-3 PUFAs. Reduced phosphatidylcholine, phosphatidylethanolamine, phosphatidylinositol, and plasmalogens were observed, whereas triacylglycerols were enriched. Loss of polyunsaturated phospholipids and accumulation of relatively saturated triacylglycerols indicate a shift toward neutral lipid storage in human MI myocardium.

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Cite

BibTeXRIS
BibTeX
@article{shiozawa2026myocardial,
  title = {{Myocardial lipid remodeling in patients with myocardial infarction undergoing cardiac surgery}},
  author = {Tomoyuki Shiozawa and Tomoyasu Kadoguchi and Hyeon-Cheol Lee-Okada and Kazunori Shimada and Satoshi Matsushita and Takehiko Yokomizo and Tetsuro Miyazaki and Tatsuro Aikawa and Hidemori Hayashi and Satoru Suwa and Atsushi Amano and Yuji Nakazato and Hiroyuki Daida and Minoru Tabata and Naoshi Fukui and Nobuho Tanaka and Hirotaka Tsuno and Tohru Minamino},
  journal = {Journal of Molecular and Cellular Cardiology Plus},
  year = {2026},
  month = oct,
  doi = {10.1016/j.jmccpl.2026.100875},
  url = {https://doi.org/10.1016/j.jmccpl.2026.100875},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Myocardial lipid remodeling in patients with myocardial infarction undergoing cardiac surgery
AU  - Tomoyuki Shiozawa
AU  - Tomoyasu Kadoguchi
AU  - Hyeon-Cheol Lee-Okada
AU  - Kazunori Shimada
AU  - Satoshi Matsushita
AU  - Takehiko Yokomizo
AU  - Tetsuro Miyazaki
AU  - Tatsuro Aikawa
AU  - Hidemori Hayashi
AU  - Satoru Suwa
AU  - Atsushi Amano
AU  - Yuji Nakazato
AU  - Hiroyuki Daida
AU  - Minoru Tabata
AU  - Naoshi Fukui
AU  - Nobuho Tanaka
AU  - Hirotaka Tsuno
AU  - Tohru Minamino
PY  - 2026
DA  - 2026/10/07
JO  - Journal of Molecular and Cellular Cardiology Plus
DO  - 10.1016/j.jmccpl.2026.100875
UR  - https://doi.org/10.1016/j.jmccpl.2026.100875
AB  - Myocardial lipid remodeling in myocardial infarction (MI) remains insufficiently characterized in human myocardium. Using liquid chromatography–mass spectrometry, we analyzed left atrial appendage tissue from patients with and without MI undergoing cardiac surgery. MI was characterized by reduced phospholipid species containing omega-3 polyunsaturated fatty acids (PUFAs) and myristic acid, together with reduced diacylglycerol species containing omega-3 PUFAs. Reduced phosphatidylcholine, phosphatidylethanolamine, phosphatidylinositol, and plasmalogens were observed, whereas triacylglycerols were enriched. Loss of polyunsaturated phospholipids and accumulation of relatively saturated triacylglycerols indicate a shift toward neutral lipid storage in human MI myocardium.
SN  - 2772-9761
ER  -