Serum Electrolyte Concentrations Are Associated With Motor Nerve Conduction Velocity in Children
- 1Kinderspital Sankt Gallen
Abstract
Axonal action potential propagation critically depends on tightly regulated intra and extracellular electrolyte concentrations and acid base homeostasis. Experimental studies have demonstrated that changes in extracellular sodium, potassium, and calcium concentrations alter axonal excitability and conduction properties. However, it remains unknown whether small variations in electrolyte concentrations within the physiological range are associated with measurable changes in nerve conduction velocity in humans. In this study, data from neurologically healthy children who underwent both nerve conduction studies and blood gas analysis were analyzed to investigate the relationship between electrolyte concentrations and median motor nerve conduction velocity. Nerve conduction velocity was significantly negatively correlated with ionized calcium concentration and positively correlated with sodium concentration, whereas no significant correlation was observed for potassium. In an a priori defined multiple linear regression model, ionized calcium, sodium, and bicarbonate remained significantly associated with nerve conduction velocity after correction for multiple testing. These findings indicate that even small variations in electrolyte concentrations within the physiological range are associated with measurable differences in peripheral nerve conduction velocity and suggest an additional contribution of acid base status to nerve conduction.
Related
- Changes in Serum MMP-9 and TIMP-1 Concentrations in Children with Inflammatory Bowel Disease over a Six-Month Observation Period
- Trace element concentrations in two oribatid mite species and their associated soil and moss habitats
- Effects of Different Concentrations of Platelet-Rich Plasma-Derived Extracellular Vesicles on Cellular Activity and Lineage-Associated Marker Expression in Tendon Stem Cells
- Serum IgE, IL-4 and IL-13 Concentrations as Th2-Associated Biomarkers in Canine Giardiasis.
- Rhinovirus C Is Associated With Severe Wheezing and Febrile Respiratory Illness in Young Children
BibTeX
@misc{broser2026serum,
title = {{Serum Electrolyte Concentrations Are Associated With Motor Nerve Conduction Velocity in Children}},
author = {P. J. Broser},
howpublished = {bioRxiv},
year = {2026},
month = oct,
doi = {10.64898/2026.10.07.757353},
url = {https://www.biorxiv.org/content/10.64898/2026.10.07.757353v1},
note = {CC BY-NC-ND},
}
RIS
TY - UNPB
TI - Serum Electrolyte Concentrations Are Associated With Motor Nerve Conduction Velocity in Children
AU - P. J. Broser
PY - 2026
DA - 2026/10/07
PB - bioRxiv
DO - 10.64898/2026.10.07.757353
UR - https://www.biorxiv.org/content/10.64898/2026.10.07.757353v1
AB - Axonal action potential propagation critically depends on tightly regulated intra and extracellular electrolyte concentrations and acid base homeostasis. Experimental studies have demonstrated that changes in extracellular sodium, potassium, and calcium concentrations alter axonal excitability and conduction properties. However, it remains unknown whether small variations in electrolyte concentrations within the physiological range are associated with measurable changes in nerve conduction velocity in humans. In this study, data from neurologically healthy children who underwent both nerve conduction studies and blood gas analysis were analyzed to investigate the relationship between electrolyte concentrations and median motor nerve conduction velocity. Nerve conduction velocity was significantly negatively correlated with ionized calcium concentration and positively correlated with sodium concentration, whereas no significant correlation was observed for potassium. In an a priori defined multiple linear regression model, ionized calcium, sodium, and bicarbonate remained significantly associated with nerve conduction velocity after correction for multiple testing. These findings indicate that even small variations in electrolyte concentrations within the physiological range are associated with measurable differences in peripheral nerve conduction velocity and suggest an additional contribution of acid base status to nerve conduction.
ER -