Redo open partial nephrectomy with ureterocalycostomy for recurrent chromophobe renal cell carcinoma: A case report of a nephron-sparing salvage strategy.
- 1Faculty of Medicine, An-Najah National University, Nablus, Palestine.
- 2Faculty of Medicine, Alexandria University, Alexandria, Egypt.
- 3Urology Department, Al Mizan Hospital, Hebron, Palestine.
Abstract
Introduction
Redo partial nephrectomy (RePN) for locally recurrent renal cell carcinoma (RCC) after prior nephron-sparing surgery (NSS) remains a challenging endeavour with limited evidence. We report a case of recurrent chromophobe RCC (ChRCC) managed by open RePN combined with reconstructive ureterocalycostomy.Material and methods
A 61-year-old hypertensive woman initially underwent right partial nephrectomy for a 1.5 × 1.2 cm lower-pole renal mass. Histopathology revealed oncocytic-variant ChRCC with indeterminate margins due to specimen fragmentation. Follow-up computed tomography (CT) at 4 months demonstrated a persistent 1.4 × 1.1 cm enhancing mass with an altered enhancement pattern and ureteric adherence, prompting redo surgery. Open RePN with ureterocalycostomy and double-J stent placement was performed through extensive adhesiolysis.Results
Histopathology confirmed focal ChRCC with negative margins (R0 resection). Post-operatively, the patient developed haemodynamic instability secondary to a urinoma (8.5 × 5.5 cm) from the renal pelvis; notably, the ureterocalycostomy remained intact. She was stabilised in the intensive care unit, and a percutaneous nephrostomy was inserted. Serum creatinine remained within normal limits throughout. Post-operative follow-up at seven weeks showed resolution of hydronephrosis on ultrasonography, and three-dimensional CT urography at 73 days demonstrated a patent collecting system with no extravasation or obstruction.Conclusions
This case demonstrates that open RePN combined with ureterocalycostomy is a feasible nephron-sparing salvage strategy in selected patients with recurrent ChRCC and complex anatomy. The approach achieved complete tumour excision and preserved renal function. Further documentation of such reconstructive NSS techniques is warranted.
Related
- Chromophobe renal cell carcinoma: addressing the translational gap toward precision oncology for advanced disease
- Prognostic value of the hemoglobin, albumin, lymphocyte, and platelet score in nonmetastatic renal cell carcinoma after nephrectomy
- Deceased donor interposition graft repair of superior mesenteric artery injury during cytoreductive nephrectomy for metastatic renal cell carcinoma
- Preoperative thymic output and T cell repertoire diversity are associated with recurrence after nephrectomy for localized renal cell carcinoma
- Colonic Recurrence of Clear Cell Renal Cell Carcinoma 13 Years After Nephrectomy: A Case Report
BibTeX
@article{amr2026redo,
title = {{Redo open partial nephrectomy with ureterocalycostomy for recurrent chromophobe renal cell carcinoma: A case report of a nephron-sparing salvage strategy.}},
author = {Maria Amr and Ibrahim Khalil and Bilal Rabah Abu Sbeih},
journal = {Central European journal of urology},
year = {2026},
month = jul,
doi = {10.5173/ceju.2026.0193},
url = {https://europepmc.org/article/MED/42904095},
note = {CC BY-NC-SA},
}
RIS
TY - JOUR
TI - Redo open partial nephrectomy with ureterocalycostomy for recurrent chromophobe renal cell carcinoma: A case report of a nephron-sparing salvage strategy.
AU - Maria Amr
AU - Ibrahim Khalil
AU - Bilal Rabah Abu Sbeih
PY - 2026
DA - 2026/07/17
JO - Central European journal of urology
DO - 10.5173/ceju.2026.0193
UR - https://europepmc.org/article/MED/42904095
AB - Introduction Redo partial nephrectomy (RePN) for locally recurrent renal cell carcinoma (RCC) after prior nephron-sparing surgery (NSS) remains a challenging endeavour with limited evidence. We report a case of recurrent chromophobe RCC (ChRCC) managed by open RePN combined with reconstructive ureterocalycostomy.Material and methods A 61-year-old hypertensive woman initially underwent right partial nephrectomy for a 1.5 × 1.2 cm lower-pole renal mass. Histopathology revealed oncocytic-variant ChRCC with indeterminate margins due to specimen fragmentation. Follow-up computed tomography (CT) at 4 months demonstrated a persistent 1.4 × 1.1 cm enhancing mass with an altered enhancement pattern and ureteric adherence, prompting redo surgery. Open RePN with ureterocalycostomy and double-J stent placement was performed through extensive adhesiolysis.Results Histopathology confirmed focal ChRCC with negative margins (R0 resection). Post-operatively, the patient developed haemodynamic instability secondary to a urinoma (8.5 × 5.5 cm) from the renal pelvis; notably, the ureterocalycostomy remained intact. She was stabilised in the intensive care unit, and a percutaneous nephrostomy was inserted. Serum creatinine remained within normal limits throughout. Post-operative follow-up at seven weeks showed resolution of hydronephrosis on ultrasonography, and three-dimensional CT urography at 73 days demonstrated a patent collecting system with no extravasation or obstruction.Conclusions This case demonstrates that open RePN combined with ureterocalycostomy is a feasible nephron-sparing salvage strategy in selected patients with recurrent ChRCC and complex anatomy. The approach achieved complete tumour excision and preserved renal function. Further documentation of such reconstructive NSS techniques is warranted.
SN - 2080-4806
SN - 2080-4873
ER -