Selected interleukins, soluble TNF-α receptors, c-reactive protein and cortisol as biomarkers of surgical trauma-induced inflammation in children.
7 affiliations
- 1Faculty of Medicine, Lazarski University, Warsaw, Poland.
- 2Polish Society of Burn Management, Cracow, Poland.
- 3Polish Mother's Health Center Institute, Lodz, Poland.
- 4Department of Epidemiology and Biostatistics, Chair of Social and Preventive Medicine, Medical University of Lodz, Lodz, Poland.
- 5Department of Intensive Care and Anesthesiology, 2nd Chair of Pediatrics, Central Clinical Hospital, Medical University of Lodz, Lodz, Poland.
- 6Department of Pediatric Surgery and Oncology, Chair of Surgical Pediatrics, Central Clinical Hospital, Medical University of Lodz, Lodz, Poland.
- 7Department of Pediatric Emergency Medicine, 2nd Chair of Pediatrics, Central Clinical Hospital, Medical University of Lodz, Lodz, Poland. [email protected].
Abstract
Purpose
To evaluate the influence of surgical trauma-induced inflammation and surgery type or presence of appendicitis on the levels of the studied cytokines, CRP and cortisol as biomarkers.Methods
A prospective study was performed of pediatric patients undergoing laparotomy or laparoscopy. The concentrations of cytokines were assessed using Luminex xMAP technology, CRP by immunoturbidimetric method, and cortisol by ELISA. Their levels were determined twice at four time points: at baseline, after 6-12 h postoperative (cortisol), 12-24 h (other markers apart from CRP), and 36-48 h (CRP).Results
Significant increases were observed in IL-6 (p = 0.001) and IL-10 (p = 0.034) in non-inflammatory patients undergoing laparotomy, and in IL-6 in inflammatory (p = 0.035) and non-inflammatory (p < 0.001) groups receiving laparoscopy. Significant increases in IL-8 (p = 0.020) and sTNFRII (p = 0.004) were demonstrated in patients with inflammation undergoing laparoscopy. Significant increased CRP levels were noted in all four examined subgroups (p = 0.003, p = 0.01, p < 0.001, p < 0.001).Conclusion
sTNFRII, CRP and IL-6 are sensitive biomarkers of surgical trauma-induced inflammation. sTNFRII and CRP are reliable indicators of the presence of appendicitis. Laparotomy resulted in a greater increase in sTNFRII levels, whereas laparoscopy stimulated CRP production more strongly. The open surgery is characterized by earlier mechanical tissue injury than laparoscopy.
Related
- Reactive derivatives for affinity labeling in the ifenprodil site of NMDA receptors
- Special Issue “The Role of Toll-like Receptors (TLRs) in Infection and Inflammation: Third Edition”
- Development of immunological reagents for the identification of biomarkers of inflammation in the common marmoset
- Blood biomarkers of long COVID: A cross-sectional evaluation of key cytokines and the coordination of inflammation
- Sequencing based dissection of inflammation associated natural killer cell remodeling in lung adenocarcinoma identifies state biomarkers and therapeutic vulnerabilities
BibTeX
@article{karawani2026selected,
title = {{Selected interleukins, soluble TNF-α receptors, c-reactive protein and cortisol as biomarkers of surgical trauma-induced inflammation in children.}},
author = {Jakub Karawani and Leszek Marzec and Jarosław Sobczak and Monika Burzyńska and Anna Sikora and Przemysław Przewratil and Janusz P Sikora},
journal = {Pediatric surgery international},
year = {2026},
month = nov,
doi = {10.1007/s00383-026-06708-9},
url = {https://europepmc.org/article/MED/42970154},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Selected interleukins, soluble TNF-α receptors, c-reactive protein and cortisol as biomarkers of surgical trauma-induced inflammation in children.
AU - Jakub Karawani
AU - Leszek Marzec
AU - Jarosław Sobczak
AU - Monika Burzyńska
AU - Anna Sikora
AU - Przemysław Przewratil
AU - Janusz P Sikora
PY - 2026
DA - 2026/11/02
JO - Pediatric surgery international
DO - 10.1007/s00383-026-06708-9
UR - https://europepmc.org/article/MED/42970154
AB - Purpose To evaluate the influence of surgical trauma-induced inflammation and surgery type or presence of appendicitis on the levels of the studied cytokines, CRP and cortisol as biomarkers.Methods A prospective study was performed of pediatric patients undergoing laparotomy or laparoscopy. The concentrations of cytokines were assessed using Luminex xMAP technology, CRP by immunoturbidimetric method, and cortisol by ELISA. Their levels were determined twice at four time points: at baseline, after 6-12 h postoperative (cortisol), 12-24 h (other markers apart from CRP), and 36-48 h (CRP).Results Significant increases were observed in IL-6 (p = 0.001) and IL-10 (p = 0.034) in non-inflammatory patients undergoing laparotomy, and in IL-6 in inflammatory (p = 0.035) and non-inflammatory (p < 0.001) groups receiving laparoscopy. Significant increases in IL-8 (p = 0.020) and sTNFRII (p = 0.004) were demonstrated in patients with inflammation undergoing laparoscopy. Significant increased CRP levels were noted in all four examined subgroups (p = 0.003, p = 0.01, p < 0.001, p < 0.001).Conclusion sTNFRII, CRP and IL-6 are sensitive biomarkers of surgical trauma-induced inflammation. sTNFRII and CRP are reliable indicators of the presence of appendicitis. Laparotomy resulted in a greater increase in sTNFRII levels, whereas laparoscopy stimulated CRP production more strongly. The open surgery is characterized by earlier mechanical tissue injury than laparoscopy.
SN - 0179-0358
SN - 1437-9813
ER -