Spike-history gating of plateau potentials enables closed-loop rewriting of CA1 representations
- 1RIKEN Center for Brain Science, Hierarchical Neural Computation RIKEN ECL Research Unit
Abstract
Behavioral time scale synaptic plasticity (BTSP) allows hippocampal CA1 neurons to form or shift place fields after a single plasticity-inducing plateau potential, but what determines when individual neurons become eligible for another plasticity event remains unclear. Here we propose that recent somatic spike history provides a cell-specific gate for plateau initiation, making neurons sensitive to rising activity after relative silence while suppressing repeated plasticity during sustained firing. In a two-compartment spiking model of CA1, this gate interacts with entorhinal input to create a feedback loop in which existing representations bias subsequent plateau locations. The resulting dynamics produce gradual place-field drift, reward-associated overrepresentation, recovery of environment-specific representations after remapping, and cross-day reinstatement. Our model further predicts that stronger residual activity biases subsequent plateaus toward previous field locations, a relationship we identify by reanalyzing experimental data. Thus, the expression of neural representations can help determine when and where they are subsequently rewritten.
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BibTeX
@misc{kurth2026spikehistory,
title = {{Spike-history gating of plateau potentials enables closed-loop rewriting of CA1 representations}},
author = {A. C. Kurth and T. Asabuki},
howpublished = {bioRxiv},
year = {2026},
month = sep,
doi = {10.64898/2026.09.15.751647},
url = {https://www.biorxiv.org/content/10.64898/2026.09.15.751647v1},
note = {CC BY},
}
RIS
TY - UNPB
TI - Spike-history gating of plateau potentials enables closed-loop rewriting of CA1 representations
AU - A. C. Kurth
AU - T. Asabuki
PY - 2026
DA - 2026/09/15
PB - bioRxiv
DO - 10.64898/2026.09.15.751647
UR - https://www.biorxiv.org/content/10.64898/2026.09.15.751647v1
AB - Behavioral time scale synaptic plasticity (BTSP) allows hippocampal CA1 neurons to form or shift place fields after a single plasticity-inducing plateau potential, but what determines when individual neurons become eligible for another plasticity event remains unclear. Here we propose that recent somatic spike history provides a cell-specific gate for plateau initiation, making neurons sensitive to rising activity after relative silence while suppressing repeated plasticity during sustained firing. In a two-compartment spiking model of CA1, this gate interacts with entorhinal input to create a feedback loop in which existing representations bias subsequent plateau locations. The resulting dynamics produce gradual place-field drift, reward-associated overrepresentation, recovery of environment-specific representations after remapping, and cross-day reinstatement. Our model further predicts that stronger residual activity biases subsequent plateaus toward previous field locations, a relationship we identify by reanalyzing experimental data. Thus, the expression of neural representations can help determine when and where they are subsequently rewritten.
ER -