Multi-tissue transcriptomics elucidate growth disparity mechanisms in the leucistic morph of Channa argus
Abstract
The leucistic northern snakehead ( Channa argus ), a leucistic morph of the species, maintains the high-quality meat and nutrient density characteristic of the wild-type populations, while its unique coloration may further enhance its market appeal. However, the genetic basis and molecular mechanism of its rapid growth rate are still unclear. In this study, transcriptome sequencing was performed on the brain, liver, and muscle tissues of leucistic northern snakehead individuals with significantly different growth rates using high-throughput sequencing technology. Through in-depth bioinformatics analysis, a series of differential pathways closely related to growth rate were identified, among which pathways such as TGF-beta signaling pathway were activated in the big group. Further functional analysis suggests that these pathways may have an important impact on the rapid growth characteristics of the leucistic northern snakehead by regulating key biological processes such as muscle growth and metabolism. This study not only provides valuable clues for revealing the molecular mechanism of the growth traits of the leucistic northern snakehead, but also lays a solid theoretical foundation for the molecular breeding of the leucistic northern snakehead and the sustainable development of the aquaculture industry.
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BibTeX
@article{fan2026multitissue,
title = {{Multi-tissue transcriptomics elucidate growth disparity mechanisms in the leucistic morph of Channa argus}},
author = {Wei Fan and Hongli Liu and Yang He and Ting Zhuo and Jun Wang and Yi Geng and Xiaoli Huang and Hao Chen and Xiaolei Jiao and Qiang Wang and Hai Yang and Yu Deng and Jian Su},
journal = {BMC Genomics},
year = {2026},
month = oct,
doi = {10.1186/s12864-026-13392-5},
url = {https://link.springer.com/10.1186/s12864-026-13392-5},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Multi-tissue transcriptomics elucidate growth disparity mechanisms in the leucistic morph of Channa argus
AU - Wei Fan
AU - Hongli Liu
AU - Yang He
AU - Ting Zhuo
AU - Jun Wang
AU - Yi Geng
AU - Xiaoli Huang
AU - Hao Chen
AU - Xiaolei Jiao
AU - Qiang Wang
AU - Hai Yang
AU - Yu Deng
AU - Jian Su
PY - 2026
DA - 2026/10/01
JO - BMC Genomics
DO - 10.1186/s12864-026-13392-5
UR - https://link.springer.com/10.1186/s12864-026-13392-5
AB - The leucistic northern snakehead ( Channa argus ), a leucistic morph of the species, maintains the high-quality meat and nutrient density characteristic of the wild-type populations, while its unique coloration may further enhance its market appeal. However, the genetic basis and molecular mechanism of its rapid growth rate are still unclear. In this study, transcriptome sequencing was performed on the brain, liver, and muscle tissues of leucistic northern snakehead individuals with significantly different growth rates using high-throughput sequencing technology. Through in-depth bioinformatics analysis, a series of differential pathways closely related to growth rate were identified, among which pathways such as TGF-beta signaling pathway were activated in the big group. Further functional analysis suggests that these pathways may have an important impact on the rapid growth characteristics of the leucistic northern snakehead by regulating key biological processes such as muscle growth and metabolism. This study not only provides valuable clues for revealing the molecular mechanism of the growth traits of the leucistic northern snakehead, but also lays a solid theoretical foundation for the molecular breeding of the leucistic northern snakehead and the sustainable development of the aquaculture industry.
SN - 1471-2164
ER -