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PreprintCC BYbioRxiv

Lasting aversive consequences of a single dose of 4-hydroxytamoxifen

  • E. J. Kyzar
  • R. Setara
  • M. Eisengart
  • S. Virkar
  • L. Rogerson
  • A. Ramirez
  • C. D. Salzman1
  1. 1Columbia University
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Abstract

4-hydroxytamoxifen (4-OHT) is commonly used to facilitate activity-dependent recombination in neurons. Here we show that one dose of 4-OHT devalues alcohol, contexts, and tastants, indicating that experimental designs using 4-OHT should control for its aversiveness. Further, reactivation of 4-OHT-responsive neurons causes conditioned taste avoidance. An activity screen coupled with graph theoretical analysis identifies candidate brain areas mediating these effects. We suggest these areas could be therapeutic targets for treating addiction.

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Cite

BibTeXRIS
BibTeX
@misc{kyzar2026lasting,
  title = {{Lasting aversive consequences of a single dose of 4-hydroxytamoxifen}},
  author = {E. J. Kyzar and R. Setara and M. Eisengart and S. Virkar and L. Rogerson and A. Ramirez and C. D. Salzman},
  howpublished = {bioRxiv},
  year = {2026},
  month = sep,
  doi = {10.64898/2026.09.16.751757},
  url = {https://www.biorxiv.org/content/10.64898/2026.09.16.751757v1},
  note = {CC BY},
}
RIS
TY  - UNPB
TI  - Lasting aversive consequences of a single dose of 4-hydroxytamoxifen
AU  - E. J. Kyzar
AU  - R. Setara
AU  - M. Eisengart
AU  - S. Virkar
AU  - L. Rogerson
AU  - A. Ramirez
AU  - C. D. Salzman
PY  - 2026
DA  - 2026/09/16
PB  - bioRxiv
DO  - 10.64898/2026.09.16.751757
UR  - https://www.biorxiv.org/content/10.64898/2026.09.16.751757v1
AB  - 4-hydroxytamoxifen (4-OHT) is commonly used to facilitate activity-dependent recombination in neurons. Here we show that one dose of 4-OHT devalues alcohol, contexts, and tastants, indicating that experimental designs using 4-OHT should control for its aversiveness. Further, reactivation of 4-OHT-responsive neurons causes conditioned taste avoidance. An activity screen coupled with graph theoretical analysis identifies candidate brain areas mediating these effects. We suggest these areas could be therapeutic targets for treating addiction.
ER  -