Skip to content
DraconiticResearch
Search Sources API
203,203 studies31 sourcesUpdated 10 min ago
Peer-reviewedCC BYScientific Reports

Establishing a simulated chronic total occlusion model for laserwire device testing using angiography, optical coherence tomography and histopathological analysis

  • Alexander B. Crichton1
  • Eniko Pomozi1
  • Deborah Vela2
  • Janak Lamichhane1
  • L. Maximilian Buja3
  • Samuel J. Virtue4
  • Rob Reyes Perez4
  • Andrew Marques4
  • Darren Kraemer4
  • Alan B. Lumsden1
  • Trisha Roy1
4 affiliations
  1. 1DeBakey Heart & Vascular Center, Houston Methodist Hospital
  2. 2The Texas Heart Institute at Baylor College of Medicine
  3. 3Department of Pathology and Laboratory Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston
  4. 4Light Matter Interaction Inc
Read full textPDFDOICite

Abstract

Peripheral artery disease (PAD) chronic total occlusions (CTOs) are challenging to simulate. The aim of this study was to evaluate a simulated human cadaveric CTO model. Simulated CTOs using either bone fragments for hard lesions or muscle/fascia for soft lesions were created in human arteries followed by endovascular crossing attempts. The primary outcome was immediate technical failure (ITF). Optical coherence tomography (OCT) and histological evaluation was also completed, and a novel laserwire prototype (Light Matter Interaction Inc.) was used in two cases. Seven hard and 1 soft CTO were created. ITF occurred in 43% of hard CTOs while the soft CTO had no technical difficulty. OCT and histopathological evaluation provided evaluation of vessel wall injury. Laserwire testing was carried out on two lesions, resulting in successful crossing showing the advantages of using this model for endovascular device testing and development.

Related

  1. From coronary computed tomography angiography to the cath lab: computed tomography-guided percutaneous coronary intervention of a high-risk left anterior descending artery lesion
    Natalia Krajewska, Łukasz Kołtowski
    Postepy w kardiologii interwencyjnej = Advances in interventional cardiologyPeer-reviewedCC BY-NC-SAFull textSurgery & anaesthesiaEurope PMCPMC
  2. Test-bolus peak attenuation for predicting aortic enhancement in coronary computed tomography angiography: an exploratory subgroup analysis
    Quantitative imaging in medicine and surgeryPeer-reviewedCC BY-NC-NDFull textMedical imaging & radiologyEurope PMC
  3. Incidental pulmonary nodules detected on computed tomography pulmonary angiography: prevalence and malignancy outcomes from a Thai tertiary-care center
    Korkate Taikerd, Thitiwat Sriprasart
    Journal of thoracic diseasePeer-reviewedCC BY-NC-NDFull textGeneral medicineEurope PMC
  4. Serial bedside retinal optical coherence tomography angiography in sepsis associated circulatory dysfunction
    André Rosa Alexandre, Gonçalo Meleiro Magalhães, Pedro Póvoa +1
    Intensive Care Medicine ExperimentalPeer-reviewedCC BYFull textGeneral medicineDOAJ
  5. Nonlinear and Vessel-Specific Association Between Coronary Artery Calcium Burden and Coronary Computed Tomography Angiography Underestimation of Coronary Stenosis
    Xuzhe Wang, Chengzhuo Wang, Yu Xie +2
    Reviews in cardiovascular medicinePeer-reviewedCC BYFull textCardiovascular medicineEurope PMC

Cite

BibTeXRIS
BibTeX
@article{crichton2026establishing,
  title = {{Establishing a simulated chronic total occlusion model for laserwire device testing using angiography, optical coherence tomography and histopathological analysis}},
  author = {Alexander B. Crichton and Eniko Pomozi and Deborah Vela and Janak Lamichhane and L. Maximilian Buja and Samuel J. Virtue and Rob Reyes Perez and Andrew Marques and Darren Kraemer and Alan B. Lumsden and Trisha Roy},
  journal = {Scientific Reports},
  year = {2026},
  month = aug,
  doi = {10.1038/s41598-026-65539-9},
  url = {https://doi.org/10.1038/s41598-026-65539-9},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Establishing a simulated chronic total occlusion model for laserwire device testing using angiography, optical coherence tomography and histopathological analysis
AU  - Alexander B. Crichton
AU  - Eniko Pomozi
AU  - Deborah Vela
AU  - Janak Lamichhane
AU  - L. Maximilian Buja
AU  - Samuel J. Virtue
AU  - Rob Reyes Perez
AU  - Andrew Marques
AU  - Darren Kraemer
AU  - Alan B. Lumsden
AU  - Trisha Roy
PY  - 2026
DA  - 2026/08/01
JO  - Scientific Reports
DO  - 10.1038/s41598-026-65539-9
UR  - https://doi.org/10.1038/s41598-026-65539-9
AB  - Peripheral artery disease (PAD) chronic total occlusions (CTOs) are challenging to simulate. The aim of this study was to evaluate a simulated human cadaveric CTO model. Simulated CTOs using either bone fragments for hard lesions or muscle/fascia for soft lesions were created in human arteries followed by endovascular crossing attempts. The primary outcome was immediate technical failure (ITF). Optical coherence tomography (OCT) and histological evaluation was also completed, and a novel laserwire prototype (Light Matter Interaction Inc.) was used in two cases. Seven hard and 1 soft CTO were created. ITF occurred in 43% of hard CTOs while the soft CTO had no technical difficulty. OCT and histopathological evaluation provided evaluation of vessel wall injury. Laserwire testing was carried out on two lesions, resulting in successful crossing showing the advantages of using this model for endovascular device testing and development.
SN  - 2045-2322
ER  -