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Peer-reviewedCC BYTrends in Neurosciences

BIN1 and Alzheimer’s disease: the tau connection

  • Pierre Dourlen
  • Devrim Kilinc
  • Isabelle Landrieu
  • Julien Chapuis
  • Jean-Charles Lambert
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Abstract

Bridging integrator 1 (BIN1) is a ubiquitously expressed protein that plays a critical role in endocytosis, trafficking and cytoskeletal dynamics. In 2010, BIN1 gene was reported as a major genetic risk factor for Alzheimer's disease (AD), which shifted the focus on its physiological and pathophysiological roles in the brain (at a time when data available were scarce). In this review, we discuss the multiple cerebral roles of BIN1, especially in regulating synaptic function, and the strong link between BIN1 and tau pathology, supported by recent evidence ranging from genetic and clinical/postmortem observations to molecular interactions.

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Cite

BibTeXRIS
BibTeX
@article{dourlen2026bin1,
  title = {{BIN1 and Alzheimer’s disease: the tau connection}},
  author = {Pierre Dourlen and Devrim Kilinc and Isabelle Landrieu and Julien Chapuis and Jean-Charles Lambert},
  journal = {Trends in Neurosciences},
  year = {2026},
  month = oct,
  doi = {10.1016/j.tins.2025.03.004},
  url = {https://hal.science/hal-05776229v1},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - BIN1 and Alzheimer’s disease: the tau connection
AU  - Pierre Dourlen
AU  - Devrim Kilinc
AU  - Isabelle Landrieu
AU  - Julien Chapuis
AU  - Jean-Charles Lambert
PY  - 2026
DA  - 2026/10/02
JO  - Trends in Neurosciences
DO  - 10.1016/j.tins.2025.03.004
UR  - https://hal.science/hal-05776229v1
AB  - Bridging integrator 1 (BIN1) is a ubiquitously expressed protein that plays a critical role in endocytosis, trafficking and cytoskeletal dynamics. In 2010, BIN1 gene was reported as a major genetic risk factor for Alzheimer's disease (AD), which shifted the focus on its physiological and pathophysiological roles in the brain (at a time when data available were scarce). In this review, we discuss the multiple cerebral roles of BIN1, especially in regulating synaptic function, and the strong link between BIN1 and tau pathology, supported by recent evidence ranging from genetic and clinical/postmortem observations to molecular interactions.
SN  - 0166-2236
SN  - 1878-108X
ER  -