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Peer-reviewedCC BY-NC-NDScandinavian journal of immunology

The Met1-Ub System in T Cells: What We Know, What We Think We Know.

  • John Rizk1
  • Mads Gyrd-Hansen1
  1. 1Department of Immunology and Microbiology, LEO Foundation Skin Immunology Research Center, University of Copenhagen, Copenhagen, Denmark.
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Abstract

Methionine 1-linked ubiquitin (Met1-Ub) is a non-degradative protein modification that is generated solely by the Linear Ub Chain Assembly Complex (LUBAC) and hydrolysed by the deubiquitinases OTULIN and CYLD. The Met1-Ub system has emerged as a critical regulator of immune receptor signalling, specially known for activating NF-κB downstream of the TNF receptor superfamily. Studies from human patients and mouse models have shown that the Met1-Ub system is also critical for the development, maintenance, and function of T cells. However, manipulation of the Met1-Ub system in T cells has yielded discrepant results, and the molecular underpinnings underlying the regulation of T cells by the Met1-Ub system remain unclear. This mini-review summarises the current consensus and highlights the unresolved questions surrounding the role of the Met1-Ub system in T cells.

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Cite

BibTeXRIS
BibTeX
@article{rizk2026met1ub,
  title = {{The Met1-Ub System in T Cells: What We Know, What We Think We Know.}},
  author = {John Rizk and Mads Gyrd-Hansen},
  journal = {Scandinavian journal of immunology},
  year = {2026},
  month = oct,
  doi = {10.1111/sji.70155},
  url = {https://europepmc.org/article/MED/42908223},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - The Met1-Ub System in T Cells: What We Know, What We Think We Know.
AU  - John Rizk
AU  - Mads Gyrd-Hansen
PY  - 2026
DA  - 2026/10/01
JO  - Scandinavian journal of immunology
DO  - 10.1111/sji.70155
UR  - https://europepmc.org/article/MED/42908223
AB  - Methionine 1-linked ubiquitin (Met1-Ub) is a non-degradative protein modification that is generated solely by the Linear Ub Chain Assembly Complex (LUBAC) and hydrolysed by the deubiquitinases OTULIN and CYLD. The Met1-Ub system has emerged as a critical regulator of immune receptor signalling, specially known for activating NF-κB downstream of the TNF receptor superfamily. Studies from human patients and mouse models have shown that the Met1-Ub system is also critical for the development, maintenance, and function of T cells. However, manipulation of the Met1-Ub system in T cells has yielded discrepant results, and the molecular underpinnings underlying the regulation of T cells by the Met1-Ub system remain unclear. This mini-review summarises the current consensus and highlights the unresolved questions surrounding the role of the Met1-Ub system in T cells.
SN  - 0300-9475
SN  - 1365-3083
ER  -