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Peer-reviewedCC BY-NC-NDAJP - Endocrinology and Metabolism

Additive effects of metformin on glucose homeostasis after metabolic-bariatric surgery in nonobese insulin-deficient diabetic rats

  • Mélanie Hirlemann
  • Mélanie Garmon
  • Lara Ribeiro-Parenti
  • Danielle Bailbé
  • Alexandra Willemetz
  • Hounayda El-Jindi Shahrour
  • Jamileh Movassat
  • Claire Carette
  • Maude Le Gall
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Abstract

Metabolic-bariatric surgery and metformin each improved glucose regulation in nonobese, insulin-deficient female GK rats. Their combination further reduced postprandial glycemic excursions without additional effects on insulin sensitivity or incretin/insulin secretion. These findings demonstrate that metformin retains metabolic activity after metabolic-bariatric surgery and improves postprandial glucose control through mechanisms distinct from surgery-induced incretin pathways. This study contributes to the ongoing discussion regarding metformin use after metabolic-bariatric surgery, particularly in insulin-deficient diabetes.

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Cite

BibTeXRIS
BibTeX
@article{hirlemann2026additive,
  title = {{Additive effects of metformin on glucose homeostasis after metabolic-bariatric surgery in nonobese insulin-deficient diabetic rats}},
  author = {Mélanie Hirlemann and Mélanie Garmon and Lara Ribeiro-Parenti and Danielle Bailbé and Alexandra Willemetz and Hounayda El-Jindi Shahrour and Jamileh Movassat and Claire Carette and Maude Le Gall},
  journal = {AJP - Endocrinology and Metabolism},
  year = {2026},
  month = oct,
  doi = {10.1152/ajpendo.00077.2026},
  url = {https://hal.science/hal-05784089v1},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - Additive effects of metformin on glucose homeostasis after metabolic-bariatric surgery in nonobese insulin-deficient diabetic rats
AU  - Mélanie Hirlemann
AU  - Mélanie Garmon
AU  - Lara Ribeiro-Parenti
AU  - Danielle Bailbé
AU  - Alexandra Willemetz
AU  - Hounayda El-Jindi Shahrour
AU  - Jamileh Movassat
AU  - Claire Carette
AU  - Maude Le Gall
PY  - 2026
DA  - 2026/10/01
JO  - AJP - Endocrinology and Metabolism
DO  - 10.1152/ajpendo.00077.2026
UR  - https://hal.science/hal-05784089v1
AB  - Metabolic-bariatric surgery and metformin each improved glucose regulation in nonobese, insulin-deficient female GK rats. Their combination further reduced postprandial glycemic excursions without additional effects on insulin sensitivity or incretin/insulin secretion. These findings demonstrate that metformin retains metabolic activity after metabolic-bariatric surgery and improves postprandial glucose control through mechanisms distinct from surgery-induced incretin pathways. This study contributes to the ongoing discussion regarding metformin use after metabolic-bariatric surgery, particularly in insulin-deficient diabetes.
SN  - 0193-1849
SN  - 1522-1555
ER  -