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Peer-reviewedCC BY 4.0Antimicrobial Agents and Chemotherapy

Dermatophytes in Argentina: species distribution, comparative identification accuracy of conventional and proteomic methods, introduction of a novel molecular identification approach, and antifungal susceptibility profiles

  • Natalia Sasoni1,2
  • María Sol Barbagelata1
  • Ivana Maldonado3
  • Luciana Farias4
  • Matias Cabeza1,2
  • Manuela Loaiza-Oliva1,2
  • María Gabriela Latorre Rapela1
  • Soledad Gamarra1
  • Norma Fernández4
  • Guillermo García-Effron1,2
4 affiliations
  1. 1Cátedra de Parasitología y Micología - Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Santa Fe, Argentina
  2. 2Laboratorio de Micología y Diagnóstico Molecular - Instituto de Salud y Ambiente (ISAL), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Santa Fe, Argentina
  3. 3Sección Microbiología, Laboratorio Central, Hospital Alemán, Buenos Aires, Argentina
  4. 4Laboratorio de Micología, División Infectología, Hospital de Clínicas José de San Martin, Catedra de Microbiología Clínica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina
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Abstract

Dermatophytosis is a frequent superficial fungal infection, yet data from Argentina remain scarce. In this multicenter study, 127 isolates consecutively collected in 2024 were analyzed using morphology, matrix-assisted laser desorption/ionization time-of-flight mass spectrometry, internal transcribed spacer sequencing, and a novel multiplex PCR assay for rapid identification. Predominant species included Trichophyton tonsurans, Trichophyton rubrum, and the Trichophyton mentagrophytes complex. Antifungal testing (CLSI M38) revealed interspecies variability: terbinafine was most active, itraconazole showed better efficacy against Microsporum canis, while fluconazole displayed limited activity.

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Cite

BibTeXRIS
BibTeX
@article{sasoni2026dermatophytes,
  title = {{Dermatophytes in Argentina: species distribution, comparative identification accuracy of conventional and proteomic methods, introduction of a novel molecular identification approach, and antifungal susceptibility profiles}},
  author = {Natalia Sasoni and María Sol Barbagelata and Ivana Maldonado and Luciana Farias and Matias Cabeza and Manuela Loaiza-Oliva and María Gabriela Latorre Rapela and Soledad Gamarra and Norma Fernández and Guillermo García-Effron},
  journal = {Antimicrobial Agents and Chemotherapy},
  year = {2026},
  month = oct,
  doi = {10.1128/aac.00796-26},
  url = {https://doi.org/10.1128/aac.00796-26},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Dermatophytes in Argentina: species distribution, comparative identification accuracy of conventional and proteomic methods, introduction of a novel molecular identification approach, and antifungal susceptibility profiles
AU  - Natalia Sasoni
AU  - María Sol Barbagelata
AU  - Ivana Maldonado
AU  - Luciana Farias
AU  - Matias Cabeza
AU  - Manuela Loaiza-Oliva
AU  - María Gabriela Latorre Rapela
AU  - Soledad Gamarra
AU  - Norma Fernández
AU  - Guillermo García-Effron
PY  - 2026
DA  - 2026/10/01
JO  - Antimicrobial Agents and Chemotherapy
DO  - 10.1128/aac.00796-26
UR  - https://doi.org/10.1128/aac.00796-26
AB  - Dermatophytosis is a frequent superficial fungal infection, yet data from Argentina remain scarce. In this multicenter study, 127 isolates consecutively collected in 2024 were analyzed using morphology, matrix-assisted laser desorption/ionization time-of-flight mass spectrometry, internal transcribed spacer sequencing, and a novel multiplex PCR assay for rapid identification. Predominant species included Trichophyton tonsurans, Trichophyton rubrum, and the Trichophyton mentagrophytes complex. Antifungal testing (CLSI M38) revealed interspecies variability: terbinafine was most active, itraconazole showed better efficacy against Microsporum canis, while fluconazole displayed limited activity.
SN  - 0066-4804
SN  - 1098-6596
ER  -