Benign Proliferative Nodules in a Giant Congenital Melanocytic Nevus: Diagnostic Challenge and Management.
- 1Department of Dermatology Joseph Raseta Befelatanana Hospital University of Antananarivo Antananarivo Madagascar univ-antananarivo.mg.
- 2Anatomic and Pathological Cytology Department Joseph Ravoahangy Andrianavalona Hospital University of Antananarivo Antananarivo Madagascar univ-antananarivo.mg.
- 3Department of Dermatology Place Kabary University of Antsiranana Antsiranana Madagascar.
Abstract
Congenital melanocytic nevi are cutaneous malformations present at birth, resulting from a benign proliferation of melanocytes. Although generally benign, they can have significant psychological impacts and carry a non-negligible risk of progression to malignant melanoma. We report a case of a giant congenital melanocytic nevus associated with a perianal mass in an infant, two and half-month-old infant, with no notable medical history, born at term. He was referred for a pigmented perianal swelling located on a large hyperpigmented plaque covering the lower back, buttocks, perineum, external genitalia, and the upper third of the thighs, consistent with a giant nevus. Multiple pigmented maculopapular satellite lesions were present, extending from the scalp to the soles of the feet. All lesions had been present since birth. The general examination was unremarkable. Doppler ultrasound revealed a well-defined, homogeneous, hypoechoic subcutaneous lesion with low vascularity, and skin biopsy confirmed a benign proliferative nodule. The proposed management included surgical excision, neurological and growth development follow-up, and psychosocial support for the infant and the parents. Six months after surgery, follow-up showed no evidence of recurrence, with the infant demonstrating normal neurological function and appropriate growth and developmental progress. This case highlights the importance of an accurate clinical and histological diagnosis and a multidisciplinary approach to management. It contributes to the limited local data from Madagascar and may contribute to the understanding of potential complications and their management.
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BibTeX
@article{rakotonandrasana2026benign,
title = {{Benign Proliferative Nodules in a Giant Congenital Melanocytic Nevus: Diagnostic Challenge and Management.}},
author = {Fenohasina Rakotonandrasana and Holy Tiana Andrianjafitrimo and Onivola Raharolahy and Andrianandrianina Mbolatiana Kiady Armando Rakotomanana and Georges Cheny Fenohasina and Voahanginirina Nathalie Ralimalala and Malalaniaina Andrianarison and Fandresena Arilala Sendrasoa and Irina Mamisoa Ranaivo and Fahafahantsoa Rapelanoro Rabenja and Lala Soavina Ramarozatovo},
journal = {Case reports in dermatological medicine},
year = {2026},
month = oct,
doi = {10.1155/crdm/9996929},
url = {https://europepmc.org/article/MED/42898947},
note = {CC BY},
}
RIS
TY - JOUR
TI - Benign Proliferative Nodules in a Giant Congenital Melanocytic Nevus: Diagnostic Challenge and Management.
AU - Fenohasina Rakotonandrasana
AU - Holy Tiana Andrianjafitrimo
AU - Onivola Raharolahy
AU - Andrianandrianina Mbolatiana Kiady Armando Rakotomanana
AU - Georges Cheny Fenohasina
AU - Voahanginirina Nathalie Ralimalala
AU - Malalaniaina Andrianarison
AU - Fandresena Arilala Sendrasoa
AU - Irina Mamisoa Ranaivo
AU - Fahafahantsoa Rapelanoro Rabenja
AU - Lala Soavina Ramarozatovo
PY - 2026
DA - 2026/10/18
JO - Case reports in dermatological medicine
DO - 10.1155/crdm/9996929
UR - https://europepmc.org/article/MED/42898947
AB - Congenital melanocytic nevi are cutaneous malformations present at birth, resulting from a benign proliferation of melanocytes. Although generally benign, they can have significant psychological impacts and carry a non-negligible risk of progression to malignant melanoma. We report a case of a giant congenital melanocytic nevus associated with a perianal mass in an infant, two and half-month-old infant, with no notable medical history, born at term. He was referred for a pigmented perianal swelling located on a large hyperpigmented plaque covering the lower back, buttocks, perineum, external genitalia, and the upper third of the thighs, consistent with a giant nevus. Multiple pigmented maculopapular satellite lesions were present, extending from the scalp to the soles of the feet. All lesions had been present since birth. The general examination was unremarkable. Doppler ultrasound revealed a well-defined, homogeneous, hypoechoic subcutaneous lesion with low vascularity, and skin biopsy confirmed a benign proliferative nodule. The proposed management included surgical excision, neurological and growth development follow-up, and psychosocial support for the infant and the parents. Six months after surgery, follow-up showed no evidence of recurrence, with the infant demonstrating normal neurological function and appropriate growth and developmental progress. This case highlights the importance of an accurate clinical and histological diagnosis and a multidisciplinary approach to management. It contributes to the limited local data from Madagascar and may contribute to the understanding of potential complications and their management.
SN - 2090-6463
SN - 2090-6471
ER -