Antibiotic susceptibility pattern of ESBLs-producing uropathogens in kidney transplant recipients in northern Iran.
- 1Department of Microbiology, Virology and Microbial Toxins, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
- 2Urology Research Center, Razi Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
- 3Pediatric Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran.
Abstract
Background
Due to the increasing global prevalence of extended-spectrum beta-lactamase (ESBL)-producing uropathogenic strains, ongoing surveillance is required to monitor drug-resistant organisms causing urinary tract infections (UTIs) in kidney transplant recipients (KTRs). This study aimed to evaluate the antibiotic resistance profiles of uropathogenic isolates in KTRs with UTIs caused by ESBL-producing strains.Methods
A total of 96 urine samples collected from KTRs were cultured on selective media and analyzed using phenotypic characterization and PCR methods. Antibiotic resistance patterns among uropathogenic isolates were evaluated using the disk diffusion and E-test methods. Data were analyzed using SPSS Version 21, and the level of significance was set at 0.05.Results
Among the 26 uropathogenic isolates, uropathogenic Escherichia coli (UPEC) was the most prevalent (15, 57.7%), followed by Klebsiella pneumoniae (10, 38.5%) and Enterococcus faecalis (1, 3.8%). The rate of ESBL-producing isolates was 72% among UPEC and K. pneumoniae isolates. Antibiotic susceptibility testing revealed that ESBL-producing uropathogens exhibited significantly higher resistance rates (p < 0.05) than non-ESBL-producing strains to cefuroxime, cefepime, trimethoprim-sulfamethoxazole, ciprofloxacin, and levofloxacin. E. faecalis showed susceptibility to vancomycin, penicillin, and ampicillin and resistance to ciprofloxacin and levofloxacin.Conclusion
The rate of ESBL-related UTIs among KTRs was notable in this study. Based on the in vitro results, fosfomycin appears to be a promising oral therapeutic option for UTIs caused by ESBL-producing uropathogens in KTRs in the study region. In addition, the high prevalence of ESBL-producing isolates underscores the potential value of targeted prophylactic strategies for high-risk patients.
Related
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- Multi-drug resistance and multiple antibiotic resistance index of uropathogens in diabetic and non-diabetic patients with urinary tract infections
- Association of eplet mismatch load and allograft injury in kidney transplant recipients
- The Tell-Tale Heart ― Persistent Immune Activation in Histologically Rejection-Free Heart Transplant Recipients ―
- Retrospective evaluation of predictors and clinical impact of postoperative delirium in liver transplant recipients
BibTeX
@article{sheikhi2026antibiotic,
title = {{Antibiotic susceptibility pattern of ESBLs-producing uropathogens in kidney transplant recipients in northern Iran.}},
author = {Raheleh Sheikhi and Mojgan Sigarchi and Ali Monfared and Masoud Khosravi and Sara Darvishvand and Afagh Hassanzadeh Rad and Elham Ramezanzade and Mohammad-Kazem Lebadi and Yalda Haghdar-Saheli and Pegah Aghajanzadeh and Ali Movassaghi},
journal = {Caspian journal of internal medicine},
year = {2026},
month = sep,
doi = {10.22088/cjim.17.3.613},
url = {https://europepmc.org/article/MED/42924352},
note = {CC BY-NC},
}
RIS
TY - JOUR
TI - Antibiotic susceptibility pattern of ESBLs-producing uropathogens in kidney transplant recipients in northern Iran.
AU - Raheleh Sheikhi
AU - Mojgan Sigarchi
AU - Ali Monfared
AU - Masoud Khosravi
AU - Sara Darvishvand
AU - Afagh Hassanzadeh Rad
AU - Elham Ramezanzade
AU - Mohammad-Kazem Lebadi
AU - Yalda Haghdar-Saheli
AU - Pegah Aghajanzadeh
AU - Ali Movassaghi
PY - 2026
DA - 2026/09/01
JO - Caspian journal of internal medicine
DO - 10.22088/cjim.17.3.613
UR - https://europepmc.org/article/MED/42924352
AB - Background Due to the increasing global prevalence of extended-spectrum beta-lactamase (ESBL)-producing uropathogenic strains, ongoing surveillance is required to monitor drug-resistant organisms causing urinary tract infections (UTIs) in kidney transplant recipients (KTRs). This study aimed to evaluate the antibiotic resistance profiles of uropathogenic isolates in KTRs with UTIs caused by ESBL-producing strains.Methods A total of 96 urine samples collected from KTRs were cultured on selective media and analyzed using phenotypic characterization and PCR methods. Antibiotic resistance patterns among uropathogenic isolates were evaluated using the disk diffusion and E-test methods. Data were analyzed using SPSS Version 21, and the level of significance was set at 0.05.Results Among the 26 uropathogenic isolates, uropathogenic Escherichia coli (UPEC) was the most prevalent (15, 57.7%), followed by Klebsiella pneumoniae (10, 38.5%) and Enterococcus faecalis (1, 3.8%). The rate of ESBL-producing isolates was 72% among UPEC and K. pneumoniae isolates. Antibiotic susceptibility testing revealed that ESBL-producing uropathogens exhibited significantly higher resistance rates (p < 0.05) than non-ESBL-producing strains to cefuroxime, cefepime, trimethoprim-sulfamethoxazole, ciprofloxacin, and levofloxacin. E. faecalis showed susceptibility to vancomycin, penicillin, and ampicillin and resistance to ciprofloxacin and levofloxacin.Conclusion The rate of ESBL-related UTIs among KTRs was notable in this study. Based on the in vitro results, fosfomycin appears to be a promising oral therapeutic option for UTIs caused by ESBL-producing uropathogens in KTRs in the study region. In addition, the high prevalence of ESBL-producing isolates underscores the potential value of targeted prophylactic strategies for high-risk patients.
SN - 2008-6164
SN - 2008-6172
ER -