Prognostic Value of the Atherogenic Index of Plasma for Severity and Cardiovascular Outcomes in Young Patients (≤35 Years) with Coronary Artery Disease: A Retrospective Study
5 affiliations
- 1Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China
- 2Beijing Institute of Heart Lung and Blood Vessel Disease, Beijing 100029, China
- 3Beijing Key Laboratory of Precision Medicine of Coronary Atherosclerotic Disease, No. 2, Anzhen Road, Chaoyang District, Beijing 100029, China
- 4Beijing Anding Hospital, Capital Medical University, Beijing 100088, China
- 5School of Public Health, Capital Medical University, Beijing 100069, China
Abstract
Background: Rising coronary artery disease (CAD) in young adults calls for early risk stratification, yet the atherogenic index of plasma (AIP) has been understudied in patients aged ≤35 years. We therefore assessed its association with coronary lesion severity and major adverse cardiovascular events (MACE) in this cohort. Methods: This single-center retrospective study enrolled 948 patients aged 18–35 years with angiographically confirmed CAD. Greater coronary lesion severity was defined as a Gensini score > 40. The association between AIP and MACE was explored. Results: During a median follow-up of 60 months, MACE occurred in 287 patients. After full adjustment, AIP as a continuous variable was independently associated with greater coronary lesion severity (OR = 1.761; 95% CI: 1.052–2.948; p = 0.031). Regarding prognosis, when AIP was dichotomized at 0.4, it was independently associated with MACE (HR = 1.350; 95% CI: 1.060–1.721; p = 0.015) in the fully adjusted model, whereas continuous AIP did not retain significance. Restricted cubic spline analysis suggested a possible U-shaped dose–response relationship between AIP and MACE (overall p < 0.001, nonlinear p = 0.051). Subgroup analyses showed that the association of AIP with MACE was generally consistent across all examined strata, with no significant interactions (all p for interaction >0.05). Conclusions: AIP was independently associated with greater coronary lesion severity and MACE in young CAD patients (≤35 years). These findings support AIP as a practical tool not only for early risk stratification but also for guiding intensive lipid-lowering therapy in this distinct population.
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BibTeX
@article{sun2026prognostic,
title = {{Prognostic Value of the Atherogenic Index of Plasma for Severity and Cardiovascular Outcomes in Young Patients (≤35 Years) with Coronary Artery Disease: A Retrospective Study}},
author = {Jiayin Sun and Jiayin Liu and Yuning Wang and Fei Zhao and Wei Han and Yujie Zhou and Dongmei Shi},
journal = {Journal of Clinical Medicine},
year = {2026},
month = oct,
doi = {10.3390/jcm15208092},
url = {https://www.mdpi.com/2077-0383/15/20/8092},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Prognostic Value of the Atherogenic Index of Plasma for Severity and Cardiovascular Outcomes in Young Patients (≤35 Years) with Coronary Artery Disease: A Retrospective Study
AU - Jiayin Sun
AU - Jiayin Liu
AU - Yuning Wang
AU - Fei Zhao
AU - Wei Han
AU - Yujie Zhou
AU - Dongmei Shi
PY - 2026
DA - 2026/10/01
JO - Journal of Clinical Medicine
DO - 10.3390/jcm15208092
UR - https://www.mdpi.com/2077-0383/15/20/8092
AB - Background: Rising coronary artery disease (CAD) in young adults calls for early risk stratification, yet the atherogenic index of plasma (AIP) has been understudied in patients aged ≤35 years. We therefore assessed its association with coronary lesion severity and major adverse cardiovascular events (MACE) in this cohort. Methods: This single-center retrospective study enrolled 948 patients aged 18–35 years with angiographically confirmed CAD. Greater coronary lesion severity was defined as a Gensini score > 40. The association between AIP and MACE was explored. Results: During a median follow-up of 60 months, MACE occurred in 287 patients. After full adjustment, AIP as a continuous variable was independently associated with greater coronary lesion severity (OR = 1.761; 95% CI: 1.052–2.948; p = 0.031). Regarding prognosis, when AIP was dichotomized at 0.4, it was independently associated with MACE (HR = 1.350; 95% CI: 1.060–1.721; p = 0.015) in the fully adjusted model, whereas continuous AIP did not retain significance. Restricted cubic spline analysis suggested a possible U-shaped dose–response relationship between AIP and MACE (overall p < 0.001, nonlinear p = 0.051). Subgroup analyses showed that the association of AIP with MACE was generally consistent across all examined strata, with no significant interactions (all p for interaction >0.05). Conclusions: AIP was independently associated with greater coronary lesion severity and MACE in young CAD patients (≤35 years). These findings support AIP as a practical tool not only for early risk stratification but also for guiding intensive lipid-lowering therapy in this distinct population.
SN - 2077-0383
ER -