Body Mass Index is Causally Associated with Calcific Tendinitis of the Shoulder: A Bidirectional Mendelian Randomization Study.
- 1Department of Orthopedics, The Seventh People's Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, 200137, People's Republic of China.
- 2School of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, People's Republic of China.
Abstract
Background
Calcific tendinitis of the shoulder is a frequent cause of pain, yet its etiology remains uncertain. We used bidirectional Mendelian randomization to investigate whether endocrine traits and body mass index (BMI) are causally related to this condition.Methods
We analyzed summary statistics from European-ancestry genome-wide association studies for diabetes-related traits, thyroid disorders, overall BMI, and female-specific adult BMI. Calcific tendinitis of the shoulder data were obtained from FinnGen Release 11. Inverse-variance weighted analysis served as the primary method, with MR-Egger, weighted median, and sensitivity analyses used to assess robustness.Results
Genetically predicted higher overall BMI was associated with an increased risk of calcific tendinitis of the shoulder (OR 1.58 per 1-SD increase, 95% CI 1.28-1.95; P < 0.001), and a similar association was observed for female-specific adult BMI (OR 1.92 per category change, 95% CI 1.17-3.13; P = 0.009). These findings remained robust in sensitivity analyses. In contrast, no convincing evidence was found to support causal effects of type 1 diabetes, type 2 diabetes, glycemic traits, or thyroid disorders on calcific tendinitis of the shoulder.Conclusion
These findings support a potential causal role of higher BMI, in calcific tendinitis of the shoulder. The endocrine traits examined here were not supported as major causal determinants.
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BibTeX
@article{zhang2026body,
title = {{Body Mass Index is Causally Associated with Calcific Tendinitis of the Shoulder: A Bidirectional Mendelian Randomization Study.}},
author = {Guo-Xu Zhang and Jie Ding and Yi-Chen Li and Chen-Xu Wang and Yi-Fei Wang and Bao-Qing Yu},
journal = {International journal of women's health},
year = {2026},
month = oct,
doi = {10.2147/ijwh.s627234},
url = {https://europepmc.org/article/MED/42936167},
note = {CC BY-NC},
}
RIS
TY - JOUR
TI - Body Mass Index is Causally Associated with Calcific Tendinitis of the Shoulder: A Bidirectional Mendelian Randomization Study.
AU - Guo-Xu Zhang
AU - Jie Ding
AU - Yi-Chen Li
AU - Chen-Xu Wang
AU - Yi-Fei Wang
AU - Bao-Qing Yu
PY - 2026
DA - 2026/10/22
JO - International journal of women's health
DO - 10.2147/ijwh.s627234
UR - https://europepmc.org/article/MED/42936167
AB - Background Calcific tendinitis of the shoulder is a frequent cause of pain, yet its etiology remains uncertain. We used bidirectional Mendelian randomization to investigate whether endocrine traits and body mass index (BMI) are causally related to this condition.Methods We analyzed summary statistics from European-ancestry genome-wide association studies for diabetes-related traits, thyroid disorders, overall BMI, and female-specific adult BMI. Calcific tendinitis of the shoulder data were obtained from FinnGen Release 11. Inverse-variance weighted analysis served as the primary method, with MR-Egger, weighted median, and sensitivity analyses used to assess robustness.Results Genetically predicted higher overall BMI was associated with an increased risk of calcific tendinitis of the shoulder (OR 1.58 per 1-SD increase, 95% CI 1.28-1.95; P < 0.001), and a similar association was observed for female-specific adult BMI (OR 1.92 per category change, 95% CI 1.17-3.13; P = 0.009). These findings remained robust in sensitivity analyses. In contrast, no convincing evidence was found to support causal effects of type 1 diabetes, type 2 diabetes, glycemic traits, or thyroid disorders on calcific tendinitis of the shoulder.Conclusion These findings support a potential causal role of higher BMI, in calcific tendinitis of the shoulder. The endocrine traits examined here were not supported as major causal determinants.
SN - 1179-1411
ER -