Left bundle branch-optimized cardiac resynchronization therapy in a dextrocardia patient: a case report

Abstract

Background: Mirror-image dextrocardia presents unique challenges for cardiac device implantation. Here, we report a case of left bundle branch-optimized cardiac resynchronization therapy (LOT-CRT) for a patient with dextrocardia and heart failure with mid-range ejection fraction (HFmrEF).

Case summary: A 69-year-old woman with mirror-image dextrocardia was electively admitted to our hospital with a complaint of chest distress and shortness of breath. Twenty-four-hour Holter showed sinus arrest with junctional rhythm, intermittent first-degree atrioventricular block with complete left bundle branch block (QRS 154 ms). Echocardiography revealed a left ventricular ejection fraction (LVEF) of 46%. In contrast to previous research utilizing the modified C315 sheath, the LOT-CRT implant was successfully achieved using a standard-curve C315 delivery sheath. At the 9-month follow-up, the patient demonstrated a significant improvement in LVEF compared with baseline (60% vs. 46%).

Discussion: This case demonstrates the clinical viability of LOT-CRT as a physiologic pacing strategy in patients with congenital heart disease. By directly targeting the conduction system, this approach may circumvent the anatomical challenges posed by traditional biventricular pacing in complex cardiac anatomies, offering a promising therapeutic alternative for resynchronization in select populations.

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BibTeX RIS

BibTeX

@article{aiyasiding2026left,
  title = {{Left bundle branch-optimized cardiac resynchronization therapy in a dextrocardia patient: a case report}},
  author = {Xiahenazi Aiyasiding and Jiandu Yang and Zhongli Chen and Yan Dai and Keping Chen},
  journal = {European Heart Journal. Case Reports},
  year = {2026},
  month = oct,
  doi = {10.1093/ehjcr/ytag801},
  url = {https://doi.org/10.1093/ehjcr/ytag801},
  note = {CC BY-NC 4.0},
}

RIS

TY  - JOUR
TI  - Left bundle branch-optimized cardiac resynchronization therapy in a dextrocardia patient: a case report
AU  - Xiahenazi Aiyasiding
AU  - Jiandu Yang
AU  - Zhongli Chen
AU  - Yan Dai
AU  - Keping Chen
PY  - 2026
DA  - 2026/10/24
JO  - European Heart Journal. Case Reports
DO  - 10.1093/ehjcr/ytag801
UR  - https://doi.org/10.1093/ehjcr/ytag801
AB  - Background: Mirror-image dextrocardia presents unique challenges for cardiac device implantation. Here, we report a case of left bundle branch-optimized cardiac resynchronization therapy (LOT-CRT) for a patient with dextrocardia and heart failure with mid-range ejection fraction (HFmrEF).  Case summary: A 69-year-old woman with mirror-image dextrocardia was electively admitted to our hospital with a complaint of chest distress and shortness of breath. Twenty-four-hour Holter showed sinus arrest with junctional rhythm, intermittent first-degree atrioventricular block with complete left bundle branch block (QRS 154 ms). Echocardiography revealed a left ventricular ejection fraction (LVEF) of 46%. In contrast to previous research utilizing the modified C315 sheath, the LOT-CRT implant was successfully achieved using a standard-curve C315 delivery sheath. At the 9-month follow-up, the patient demonstrated a significant improvement in LVEF compared with baseline (60% vs. 46%).  Discussion: This case demonstrates the clinical viability of LOT-CRT as a physiologic pacing strategy in patients with congenital heart disease. By directly targeting the conduction system, this approach may circumvent the anatomical challenges posed by traditional biventricular pacing in complex cardiac anatomies, offering a promising therapeutic alternative for resynchronization in select populations.
SN  - 2514-2119
ER  -

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