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Peer-reviewedCC BY 4.0PLOS One

Clinicopathological characteristics and prognosis of melanoma: A retrospective cohort study in Xinjiang, China

  • Caoying Wu1
  • Yongting Yang2
  • Chun Wang3
  • Yaoyuan Shen4
  • Maimaitili Buheliqimu5
  • Mahan Yeledan6
  • Yuan Ding
  • Xiaojing Kang
6 affiliations
  1. 1Xinjiang Medical University, Urumqi, Xinjiang, China
  2. 2Department of Dermatology and Venereology, People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang, China
  3. 3Xinjiang Key Laboratory of Dermatology Research, Urumqi, Xinjiang, China
  4. 4Xinjiang Clinical Research Center for Dermatology and Venereology, Urumqi, Xinjiang, China
  5. 5Department of Pathology, People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang, China
  6. 6Department of Medical Research and Translational Management, People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang, China
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Abstract

The incidence of melanoma is substantially lower in Asians than in Caucasians. This study retrospectively analyzed 355 patients in Xinjiang, China, to delineate the clinicopathological features and prognosis of melanoma in this region. The median overall survival (OS) and disease-free survival (DFS) were 78.0 and 46.0 months with 1-, 3-, and 5-year OS/DFS rates of 83.3%/68.3%/57.0% and 80.4%/59.5%/43.4%, respectively. Multivariate analysis identified advanced AJCC stage and elevated LDH as independent predictors of poorer OS. For DFS, AJCC stage, presence of metastasis, elevated LDH, and aCCI predicted worse outcomes, while adjuvant therapy was protective. Crucially, subtype-specific determinants emerged: aCCI independently predicted OS (HR = 18.42, P = 0.005) and DFS (HR = 4.91, P = 0.019) in CM, while higher BMI was associated with poorer DFS in AM (HR = 3.58, P = 0.019). These findings underscore the need for subtype-aware clinical management in this region.

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Cite

BibTeXRIS
BibTeX
@article{wu2026clinicopathological,
  title = {{Clinicopathological characteristics and prognosis of melanoma: A retrospective cohort study in Xinjiang, China}},
  author = {Caoying Wu and Yongting Yang and Chun Wang and Yaoyuan Shen and Maimaitili Buheliqimu and Mahan Yeledan and Yuan Ding and Xiaojing Kang},
  journal = {PLOS One},
  year = {2026},
  month = sep,
  doi = {10.1371/journal.pone.0357383},
  url = {https://doi.org/10.1371/journal.pone.0357383},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Clinicopathological characteristics and prognosis of melanoma: A retrospective cohort study in Xinjiang, China
AU  - Caoying Wu
AU  - Yongting Yang
AU  - Chun Wang
AU  - Yaoyuan Shen
AU  - Maimaitili Buheliqimu
AU  - Mahan Yeledan
AU  - Yuan Ding
AU  - Xiaojing Kang
PY  - 2026
DA  - 2026/09/09
JO  - PLOS One
DO  - 10.1371/journal.pone.0357383
UR  - https://doi.org/10.1371/journal.pone.0357383
AB  - The incidence of melanoma is substantially lower in Asians than in Caucasians. This study retrospectively analyzed 355 patients in Xinjiang, China, to delineate the clinicopathological features and prognosis of melanoma in this region. The median overall survival (OS) and disease-free survival (DFS) were 78.0 and 46.0 months with 1-, 3-, and 5-year OS/DFS rates of 83.3%/68.3%/57.0% and 80.4%/59.5%/43.4%, respectively. Multivariate analysis identified advanced AJCC stage and elevated LDH as independent predictors of poorer OS. For DFS, AJCC stage, presence of metastasis, elevated LDH, and aCCI predicted worse outcomes, while adjuvant therapy was protective. Crucially, subtype-specific determinants emerged: aCCI independently predicted OS (HR = 18.42, P = 0.005) and DFS (HR = 4.91, P = 0.019) in CM, while higher BMI was associated with poorer DFS in AM (HR = 3.58, P = 0.019). These findings underscore the need for subtype-aware clinical management in this region.
SN  - 1932-6203
ER  -