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Peer-reviewedCC BY 4.0Journal of Global Antimicrobial Resistance

Global lessons from antibiotic resistance: metformin-hydrolyzing genes in transposable elements, a new threat for type II diabetic patients?

  • Tram Vo
  • Vicky Merhej
  • Christina Isber
  • Pierre Pontarotti
  • Fadi Bittar
  • Jean-Marc Rolain
Open at sourcePDFDOICite

Abstract

Objectives:To investigate the evolutionary origin, genomic mobility, and potential dissemination of metformin-hydrolyzing genes (mfmAB), and to assess whether environmental selection by metformin pollution may drive the emergence of transferable pharmaceutical-degrading traits analogous to antibiotic resistance.

Methods:Large-scale comparative genomics was performed using publicly available bacterial genomes carrying mfmAB homologs. Phylogenomic reconstruction, average nucleotide identity analysis, genomic context comparison, plasmid characterization, and insertion sequence mapping were used to infer evolutionary history and identify mechanisms of horizontal gene transfer.

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Cite

BibTeXRIS
BibTeX
@article{vo2026global,
  title = {{Global lessons from antibiotic resistance: metformin-hydrolyzing genes in transposable elements, a new threat for type II diabetic patients?}},
  author = {Tram Vo and Vicky Merhej and Christina Isber and Pierre Pontarotti and Fadi Bittar and Jean-Marc Rolain},
  journal = {Journal of Global Antimicrobial Resistance},
  year = {2026},
  month = sep,
  doi = {10.1016/j.jgar.2026.08.026},
  url = {https://amu.hal.science/hal-05745000v1},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Global lessons from antibiotic resistance: metformin-hydrolyzing genes in transposable elements, a new threat for type II diabetic patients?
AU  - Tram Vo
AU  - Vicky Merhej
AU  - Christina Isber
AU  - Pierre Pontarotti
AU  - Fadi Bittar
AU  - Jean-Marc Rolain
PY  - 2026
DA  - 2026/09/10
JO  - Journal of Global Antimicrobial Resistance
DO  - 10.1016/j.jgar.2026.08.026
UR  - https://amu.hal.science/hal-05745000v1
AB  - Objectives:To investigate the evolutionary origin, genomic mobility, and potential dissemination of metformin-hydrolyzing genes (mfmAB), and to assess whether environmental selection by metformin pollution may drive the emergence of transferable pharmaceutical-degrading traits analogous to antibiotic resistance.  Methods:Large-scale comparative genomics was performed using publicly available bacterial genomes carrying mfmAB homologs. Phylogenomic reconstruction, average nucleotide identity analysis, genomic context comparison, plasmid characterization, and insertion sequence mapping were used to infer evolutionary history and identify mechanisms of horizontal gene transfer.
SN  - 2213-7165
SN  - 2213-7173
ER  -