Frailty or multimorbidity: which matters most for the prognosis of hospitalised older adults?
- 1School of Medicine and Surgery, University of Milano-Bicocca, Milano, Italy
- 2Fondazione IRCCS San Gerardo Dei Tintori, Monza, Italy
- 3Centro Studi Dipartimentale Sulla Medicina Della Complessità e Cure Palliative Virgilio Floriani, University of Milano-Bicocca, Monza, Italy
Abstract
Objective: Frailty and multimorbidity frequently coexist in older adults, yet their independent and combined prognostic implications in hospitalised patients remain incompletely understood. This study aimed to investigate their prognostic contribution to six-month mortality across different operationalisations of multimorbidity and levels of frailty severity.
Methods: This observational study used prospectively collected data from adults aged ≥65 years admitted to an Acute Geriatric Unit. Frailty was assessed with the Clinical Frailty Scale (CFS), while multimorbidity was operationalised as ≥2 co-existing long-term conditions (2+LTCs), and further evaluated using the Charlson Comorbidity Index (CCI) and single disease count (SC). The primary outcome was six-month mortality. Adjusted Cox models assessed independent associations of frailty and multimorbidity with mortality, as well as their interactions.
Results: Among 2,006 patients (mean age 85.6 years; 53% female), both 2+LTCs and at least moderate frailty (CFS ≥6) were highly prevalent, each affecting 70% of participants. Overall, 445 patients (22%) died within six months after discharge. Frailty was associated with increased mortality both in the presence and absence of 2+LTCs. Across secondary models, each 1-point increase in CFS was associated with 50% higher mortality risk (all P < 0.001). 2+LTCs and CCI retained independent associations with mortality, whereas SC did not. A significant negative interaction was observed between frailty and CCI (P for interaction = 0.011), indicating attenuation of the prognostic contribution of weighted disease burden at higher frailty levels.
Conclusions: Frailty showed the strongest association with six-month mortality, whereas the prognostic significance of multimorbidity varied according to its operationalisation and frailty severity. These findings support broader integration of frailty assessment into prognostic stratification in hospitalised older adults.
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BibTeX
@article{finazzi2026frailty,
title = {{Frailty or multimorbidity: which matters most for the prognosis of hospitalised older adults?}},
author = {Alberto Finazzi and Emma Esposito and Chukwuma Okoye and Maria Cristina Ferrara and Elena Pinardi and Martina Marelli and Eleonora Cucini and Martina Manna and Gianlorenzo Scaccabarozzi and Giuseppe Bellelli},
journal = {The Journal of Nutrition, Health \& Aging},
year = {2026},
month = oct,
doi = {10.1016/j.jnha.2026.101023},
url = {https://doi.org/10.1016/j.jnha.2026.101023},
note = {CC BY-NC-ND 4.0},
}
RIS
TY - JOUR
TI - Frailty or multimorbidity: which matters most for the prognosis of hospitalised older adults?
AU - Alberto Finazzi
AU - Emma Esposito
AU - Chukwuma Okoye
AU - Maria Cristina Ferrara
AU - Elena Pinardi
AU - Martina Marelli
AU - Eleonora Cucini
AU - Martina Manna
AU - Gianlorenzo Scaccabarozzi
AU - Giuseppe Bellelli
PY - 2026
DA - 2026/10/28
JO - The Journal of Nutrition, Health & Aging
DO - 10.1016/j.jnha.2026.101023
UR - https://doi.org/10.1016/j.jnha.2026.101023
AB - Objective: Frailty and multimorbidity frequently coexist in older adults, yet their independent and combined prognostic implications in hospitalised patients remain incompletely understood. This study aimed to investigate their prognostic contribution to six-month mortality across different operationalisations of multimorbidity and levels of frailty severity. Methods: This observational study used prospectively collected data from adults aged ≥65 years admitted to an Acute Geriatric Unit. Frailty was assessed with the Clinical Frailty Scale (CFS), while multimorbidity was operationalised as ≥2 co-existing long-term conditions (2+LTCs), and further evaluated using the Charlson Comorbidity Index (CCI) and single disease count (SC). The primary outcome was six-month mortality. Adjusted Cox models assessed independent associations of frailty and multimorbidity with mortality, as well as their interactions. Results: Among 2,006 patients (mean age 85.6 years; 53% female), both 2+LTCs and at least moderate frailty (CFS ≥6) were highly prevalent, each affecting 70% of participants. Overall, 445 patients (22%) died within six months after discharge. Frailty was associated with increased mortality both in the presence and absence of 2+LTCs. Across secondary models, each 1-point increase in CFS was associated with 50% higher mortality risk (all P < 0.001). 2+LTCs and CCI retained independent associations with mortality, whereas SC did not. A significant negative interaction was observed between frailty and CCI (P for interaction = 0.011), indicating attenuation of the prognostic contribution of weighted disease burden at higher frailty levels. Conclusions: Frailty showed the strongest association with six-month mortality, whereas the prognostic significance of multimorbidity varied according to its operationalisation and frailty severity. These findings support broader integration of frailty assessment into prognostic stratification in hospitalised older adults.
SN - 1279-7707
SN - 1760-4788
ER -