Post-embolization dynamic changes in Obsidio Conformable Embolic: volume and radiodensity analysis.
10 affiliations
- 1Georgetown University School of Medicine, 3700 Reservoir Road NW, Washington, DC, 20007, USA.
- 2Department of Radiology, Emory University School of Medicine, 1364 Clifton Rd NE, Atlanta, GA, 30322, USA.
- 3Division of Interventional Radiology, MedStar Georgetown University Hospital, 3800 Reservoir Road NW, Washington, DC, 20007, USA.
- 4HIV and AIDS Malignancy Branch, Center for Cancer Research, NCI, Bethesda, MD, USA.
- 5Boston Scientific Corporation, 300 Boston Scientific Way, Marlborough, MA, 01752, USA.
- 6Department of Interventional Radiology, University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX, 77030, USA.
- 7Georgetown University School of Medicine, 3700 Reservoir Road NW, Washington, DC, 20007, USA. [email protected].
- 8Division of Interventional Radiology, MedStar Georgetown University Hospital, 3800 Reservoir Road NW, Washington, DC, 20007, USA. [email protected].
- 9Lombardi Comprehensive Cancer Center, 3800 Reservoir Rd NW, Washington, DC, 20007, USA. [email protected].
- 10Fischell Department of Bioengineering, University of Maryland College Park, 3102 A. James Clark Hall, College Park, MD, 20742, USA. [email protected].
Abstract
Purpose
To characterize the temporal dynamic and clinical remodeling of the Obsidio™ Conformable Embolic (Obsidio) post endovascular delivery using longitudinal quantitative CT volumetry and Hounsfield unit (HU) attenuation.Materials and methods
This retrospective, single-center cohort study included 21 patients (30 vessels) embolized with Obsidio for acute hemorrhage or hypervascular tumor between 2023 and 2026. Patients had at least two follow-up computed tomography (CT) scans. The primary endpoint was the percent change in embolic cast volume and HU attenuation, measured using standardized Picture Archiving and Communication System (PACS) segmentation tools. Secondary endpoints included assessment for recanalization.Results
All embolizations were technically successful (100%). On the first follow-up CT (median 12 days), the mean Obsidio volume was 89.33 ± 13.86% of the original volume (p = 0.0002). On the second follow-up (median 36 days), the volume was 79.51 ± 19.76% of baseline volume (p = 0.0004), representing 20.49% reduction. On third follow-up CT (median 76 days), volume was 85.2 ± 18.92% (p = 0.047). On the fourth follow-up CT, volume was 66.76 ± 16.9% (p = 0.0048). On the fifth follow-up CT, volume was 60.15 ± 3.15% (p = 0.00001) The average volume reduction rate decelerated from 0.99%/day to 0.71%/day to 0.17%/day then stabilized at 0.2%/day. Concurrently, mean Hounsfield unit attenuation increased by 4.85% (p = 0.06) on the second follow-up CT scan. No evidence of recanalization, distal embolization, or cast fragmentation was observed on any of CT scans.Conclusion
The Obsidio embolic cast undergoes progressive reduction in volume and increase in HU attenuation over time without evidence of vessel recanalization. This temporal dynamic of Obsidio embolic is consistent with bioresorption of its gelatin and water components, supporting the concept of persistent occlusion via in vivo remodeling.
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BibTeX
@article{harraka2026postembolization,
title = {{Post-embolization dynamic changes in Obsidio Conformable Embolic: volume and radiodensity analysis.}},
author = {Mohamad Harraka and Radhika Amin and Amir Pourmorteza and Emil I Cohen and Bahman Afsari and Saher S Sabri and Filip Banovac and Heather Bomberger and Joshua Jones and Peiman Habibollahi and Nariman Nezami},
journal = {CVIR endovascular},
year = {2026},
month = oct,
doi = {10.1186/s42155-026-00792-7},
url = {https://europepmc.org/article/MED/42925368},
note = {CC BY},
}
RIS
TY - JOUR
TI - Post-embolization dynamic changes in Obsidio Conformable Embolic: volume and radiodensity analysis.
AU - Mohamad Harraka
AU - Radhika Amin
AU - Amir Pourmorteza
AU - Emil I Cohen
AU - Bahman Afsari
AU - Saher S Sabri
AU - Filip Banovac
AU - Heather Bomberger
AU - Joshua Jones
AU - Peiman Habibollahi
AU - Nariman Nezami
PY - 2026
DA - 2026/10/24
JO - CVIR endovascular
DO - 10.1186/s42155-026-00792-7
UR - https://europepmc.org/article/MED/42925368
AB - Purpose To characterize the temporal dynamic and clinical remodeling of the Obsidio™ Conformable Embolic (Obsidio) post endovascular delivery using longitudinal quantitative CT volumetry and Hounsfield unit (HU) attenuation.Materials and methods This retrospective, single-center cohort study included 21 patients (30 vessels) embolized with Obsidio for acute hemorrhage or hypervascular tumor between 2023 and 2026. Patients had at least two follow-up computed tomography (CT) scans. The primary endpoint was the percent change in embolic cast volume and HU attenuation, measured using standardized Picture Archiving and Communication System (PACS) segmentation tools. Secondary endpoints included assessment for recanalization.Results All embolizations were technically successful (100%). On the first follow-up CT (median 12 days), the mean Obsidio volume was 89.33 ± 13.86% of the original volume (p = 0.0002). On the second follow-up (median 36 days), the volume was 79.51 ± 19.76% of baseline volume (p = 0.0004), representing 20.49% reduction. On third follow-up CT (median 76 days), volume was 85.2 ± 18.92% (p = 0.047). On the fourth follow-up CT, volume was 66.76 ± 16.9% (p = 0.0048). On the fifth follow-up CT, volume was 60.15 ± 3.15% (p = 0.00001) The average volume reduction rate decelerated from 0.99%/day to 0.71%/day to 0.17%/day then stabilized at 0.2%/day. Concurrently, mean Hounsfield unit attenuation increased by 4.85% (p = 0.06) on the second follow-up CT scan. No evidence of recanalization, distal embolization, or cast fragmentation was observed on any of CT scans.Conclusion The Obsidio embolic cast undergoes progressive reduction in volume and increase in HU attenuation over time without evidence of vessel recanalization. This temporal dynamic of Obsidio embolic is consistent with bioresorption of its gelatin and water components, supporting the concept of persistent occlusion via in vivo remodeling.
SN - 2520-8934
ER -