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Peer-reviewedCC BYBMC Pediatrics

Predictive value of cerebral doppler resistive index in premature infants with hemodynamically significant patent ductus arteriosus

  • Burak Ceran1
  • Evrim Alyamaç Dizdar1
  • Rana Beyoğlu2
  • Nahide Kutbay Altuğ3
  • Esin Okman1
  • Davut Bozkaya1
  • Mustafa Şenol Akın1
  • Fatma Nur Sari1
  1. 1Department of Neonatology, Ankara Bilkent City Hospital, NICU, University of Health Sciences
  2. 2Department of Pediatric Radiology, Ankara Bilkent City Hospital, University of Health Sciences
  3. 3Department of Pediatric Cardiology, Ankara Bilkent City Hospital, University of Health Sciences
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Abstract

Background To evaluate cerebral Doppler ultrasonography parameters for predicting hemodynamically significant patent ductus arteriosus (hsPDA) in very premature infants. Methods This prospective cohort study included preterm infants (gestational age [GA] ≤ 30 weeks) who were admitted to a tertiary neonatal intensive care unit. Blood flow velocities, resistive and pulsatility indices of anterior cerebral artery (ACA) were measured at the first 24 and 72 h of life using transcranial Doppler ultrasound. The pediatric cardiologist performed echocardiographic evaluations of all infants at 72 h postnatally. Results A total of 77 infants (27 and 50 in the hsPDA and non-hsPDA groups) were included. Mean GA was 27.9 ± 2 and 28.6 ± 1.6 weeks, and mean birth weight was 1056 ± 248 and 1106 ± 269 g in the hsPDA and non-hsPDA groups, respectively; (p = 0.094, p = 0.46). Infants in the hsPDA group had significantly higher pulsatility index and resistive index (RI) than those in the non-hsPDA group at 24 h (p < 0.001 and p < 0.001, respectively). Multivariate analysis revealed that ACA RI above 0.75 at 24 h was an independent predictor for hsPDA. Conclusion ACA RI measurement may have a potential role, in combination with other clinical parameters, in the early prediction of hsPDA in premature infants; however, further studies are required to validate these findings.

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Cite

BibTeXRIS
BibTeX
@article{ceran2026predictive,
  title = {{Predictive value of cerebral doppler resistive index in premature infants with hemodynamically significant patent ductus arteriosus}},
  author = {Burak Ceran and Evrim Alyamaç Dizdar and Rana Beyoğlu and Nahide Kutbay Altuğ and Esin Okman and Davut Bozkaya and Mustafa Şenol Akın and Fatma Nur Sari},
  journal = {BMC Pediatrics},
  year = {2026},
  month = jul,
  doi = {10.1186/s12887-026-07144-3},
  url = {https://doi.org/10.1186/s12887-026-07144-3},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Predictive value of cerebral doppler resistive index in premature infants with hemodynamically significant patent ductus arteriosus
AU  - Burak Ceran
AU  - Evrim Alyamaç Dizdar
AU  - Rana Beyoğlu
AU  - Nahide Kutbay Altuğ
AU  - Esin Okman
AU  - Davut Bozkaya
AU  - Mustafa Şenol Akın
AU  - Fatma Nur Sari
PY  - 2026
DA  - 2026/07/01
JO  - BMC Pediatrics
DO  - 10.1186/s12887-026-07144-3
UR  - https://doi.org/10.1186/s12887-026-07144-3
AB  - Background To evaluate cerebral Doppler ultrasonography parameters for predicting hemodynamically significant patent ductus arteriosus (hsPDA) in very premature infants. Methods This prospective cohort study included preterm infants (gestational age [GA] ≤ 30 weeks) who were admitted to a tertiary neonatal intensive care unit. Blood flow velocities, resistive and pulsatility indices of anterior cerebral artery (ACA) were measured at the first 24 and 72 h of life using transcranial Doppler ultrasound. The pediatric cardiologist performed echocardiographic evaluations of all infants at 72 h postnatally. Results A total of 77 infants (27 and 50 in the hsPDA and non-hsPDA groups) were included. Mean GA was 27.9 ± 2 and 28.6 ± 1.6 weeks, and mean birth weight was 1056 ± 248 and 1106 ± 269 g in the hsPDA and non-hsPDA groups, respectively; (p = 0.094, p = 0.46). Infants in the hsPDA group had significantly higher pulsatility index and resistive index (RI) than those in the non-hsPDA group at 24 h (p < 0.001 and p < 0.001, respectively). Multivariate analysis revealed that ACA RI above 0.75 at 24 h was an independent predictor for hsPDA. Conclusion ACA RI measurement may have a potential role, in combination with other clinical parameters, in the early prediction of hsPDA in premature infants; however, further studies are required to validate these findings.
SN  - 1471-2431
ER  -