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Peer-reviewedCC BYMedicine

Burden of CNS neoplasms in the Middle East and North Africa from 1990 to 2023, with projections to 2050: Insights from Global Burden of Disease.

  • Ibraheem Altamimi1
  • Alaa Alanazi2
  • Abdullah Abdulaziz Alnaim3
  • Ahmed Khalid Alzahrani4
  • Yousef Saeed Alzahrani5
  • Abdulelah Mohammed Abdullah Alsakti6
  • Norah Abdullah Alodhaib7
  • Ali Abdulhakim Alhakeem8
  • Mohammed Mastour Alharthi9
  • Raghad Emad Alhalabi10
  • Aalaa Saleh11
  • Jaber Abdullah Alshahrani12
12 affiliations
  1. 1Dermatology Department, King Abdulaziz Medical City, Riyadh, Saudi Arabia.
  2. 2Department of Medical Surgical Nursing, College of Nursing, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia.
  3. 3King Faisal University, Al-Ahsa, Saudi Arabia.
  4. 4College of Medicine, Shaqra campus, Shaqra University, Shaqra, Saudi Arabia.
  5. 5College of Medicine, Jeddah University, Jeddah, Saudi Arabia.
  6. 6King Khalid University, Abha, Saudi Arabia.
  7. 7College of Medicine, Qassim University, Qassim, Saudi Arabia.
  8. 8College of Medicine, King Faisal University, Hofuf, Saudi Arabia.
  9. 9Ibn Sina National College, Jeddah, Saudi Arabia.
  10. 10Batterjee Medical College (BMC), Asir, Saudi Arabia.
  11. 11Faculty of Medicine, Lebanese University, Beirut, Lebanon.
  12. 12Armed Forces Hospital Southern Region, Ministry of Defense Health Services, Khamis Mushait, Saudi Arabia.
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Abstract

Central nervous system (CNS) neoplasms are uncommon but highly consequential malignancies that account for substantial neurological disability and premature mortality. The Middle East and North Africa (MENA) region is marked by rapid population growth, aging, and uneven health system capacity, yet comprehensive long-term evaluations of CNS neoplasm burden across countries, sexes, and age groups remain limited. We analyzed data from the Global Burden of Disease 2023 study to assess trends in incidence, prevalence, and mortality from CNS neoplasms in the MENA region from 1990 to 2023, with projections to 2050. Age-standardized incidence, prevalence, and mortality rates per 1,00,000 population were estimated. Temporal trends were evaluated using Joinpoint regression to calculate annual percent change and average annual percent change (AAPC) with 95% confidence intervals. Analyses were stratified by sex, age group, and country. Between 1990 and 2023, the age-standardized mortality rate remained largely stable with a small but significant upward trend (AAPC 0.09%). Mortality rates were consistently higher among males. Adults aged 20 years and older experienced rising age-standardized mortality (AAPC 0.58%), whereas mortality declined among individuals younger than 20 years (AAPC-0.90%). Incidence increased in both absolute numbers and age-standardized rates (AAPC 0.42%). Prevalence also rose steadily, with the age-standardized prevalence rate increasing from 13.46 to 19.51 per 1,00,000 (AAPC 1.13%), driven mainly by adults. The burden of CNS neoplasms in the MENA region has intensified over the past 3 decades, highlighting the need for improved surveillance, earlier diagnosis, and expanded access to specialized neuro-oncological care.

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Cite

BibTeXRIS
BibTeX
@article{altamimi2026burden,
  title = {{Burden of CNS neoplasms in the Middle East and North Africa from 1990 to 2023, with projections to 2050: Insights from Global Burden of Disease.}},
  author = {Ibraheem Altamimi and Alaa Alanazi and Abdullah Abdulaziz Alnaim and Ahmed Khalid Alzahrani and Yousef Saeed Alzahrani and Abdulelah Mohammed Abdullah Alsakti and Norah Abdullah Alodhaib and Ali Abdulhakim Alhakeem and Mohammed Mastour Alharthi and Raghad Emad Alhalabi and Aalaa Saleh and Jaber Abdullah Alshahrani},
  journal = {Medicine},
  year = {2026},
  month = oct,
  doi = {10.1097/md.0000000000051128},
  url = {https://europepmc.org/article/MED/42888625},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Burden of CNS neoplasms in the Middle East and North Africa from 1990 to 2023, with projections to 2050: Insights from Global Burden of Disease.
AU  - Ibraheem Altamimi
AU  - Alaa Alanazi
AU  - Abdullah Abdulaziz Alnaim
AU  - Ahmed Khalid Alzahrani
AU  - Yousef Saeed Alzahrani
AU  - Abdulelah Mohammed Abdullah Alsakti
AU  - Norah Abdullah Alodhaib
AU  - Ali Abdulhakim Alhakeem
AU  - Mohammed Mastour Alharthi
AU  - Raghad Emad Alhalabi
AU  - Aalaa Saleh
AU  - Jaber Abdullah Alshahrani
PY  - 2026
DA  - 2026/10/01
JO  - Medicine
DO  - 10.1097/md.0000000000051128
UR  - https://europepmc.org/article/MED/42888625
AB  - Central nervous system (CNS) neoplasms are uncommon but highly consequential malignancies that account for substantial neurological disability and premature mortality. The Middle East and North Africa (MENA) region is marked by rapid population growth, aging, and uneven health system capacity, yet comprehensive long-term evaluations of CNS neoplasm burden across countries, sexes, and age groups remain limited. We analyzed data from the Global Burden of Disease 2023 study to assess trends in incidence, prevalence, and mortality from CNS neoplasms in the MENA region from 1990 to 2023, with projections to 2050. Age-standardized incidence, prevalence, and mortality rates per 1,00,000 population were estimated. Temporal trends were evaluated using Joinpoint regression to calculate annual percent change and average annual percent change (AAPC) with 95% confidence intervals. Analyses were stratified by sex, age group, and country. Between 1990 and 2023, the age-standardized mortality rate remained largely stable with a small but significant upward trend (AAPC 0.09%). Mortality rates were consistently higher among males. Adults aged 20 years and older experienced rising age-standardized mortality (AAPC 0.58%), whereas mortality declined among individuals younger than 20 years (AAPC-0.90%). Incidence increased in both absolute numbers and age-standardized rates (AAPC 0.42%). Prevalence also rose steadily, with the age-standardized prevalence rate increasing from 13.46 to 19.51 per 1,00,000 (AAPC 1.13%), driven mainly by adults. The burden of CNS neoplasms in the MENA region has intensified over the past 3 decades, highlighting the need for improved surveillance, earlier diagnosis, and expanded access to specialized neuro-oncological care.
SN  - 0304-5412
SN  - 1536-5964
ER  -