Assessment of the Efficacy and Safety of CyberKnife Radiosurgery on Optic Nerve Sheath Meningiomas.
5 affiliations
- 1Senior Department of Ophthalmology, Chinese PLA General Hospital & Chinese PLA Medical School, Beijing 100853, China.
- 2Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin 300384, China.
- 3Department of Ophthalmology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.
- 4Department of Ophthalmology, Air Force Medical Center, Beijing 100142, China.
- 5Senior Department of Neurosurgery, Chinese PLA General Hospital & Chinese PLA Medical School, Beijing 100853, China.
Abstract
The purpose of this study was to evaluate the efficacy and safety of CyberKnife (CK) radiosurgery in patients with optic nerve sheath meningiomas (ONSM). We retrospectively identified patients with ONSM treated with CK between January 2020 and January 2024 from the Database of Chinese Neuro-Ophthalmic Diseases. CK was delivered at 23-25 Gy in 5 fractions. Best-corrected visual acuity (BCVA) and visual field mean deviation (VF MD) were assessed before treatment and at the final follow-up, with a median visual follow-up of 36 months (range, 26-64 months). Tumor volume and CK-related complications were also evaluated. Twenty patients (22 affected eyes; 2 with bilateral involvement) were included. Treatment success was achieved in 90.9% (20/22) of eyes, including improvement in 59.1% (13/22) and stable visual function in 31.8% (7/22), whereas 9.1% (2/22) worsened. Among the 12 eyes with available VF MD data, 91.7% (11/12) improved and 8.3% (1/12) worsened. Spearman correlation analysis revealed that poorer baseline BCVA (r = 0.457, p = 0.032) and a longer interval from onset to CK (r = 0.450, p = 0.036) were associated with poorer visual outcomes, whereas age and tumor volume were not significantly associated with visual changes (p > 0.05). MRI follow-up was available for 13 patients (14 eyes), with tumor control achieved in all 14 eyes. No serious treatment-related complications were observed. CK hypofractionated radiosurgery may preserve and improve visual function in ONSM, providing a potentially safe and effective treatment option.
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BibTeX
@article{wang2026assessment,
title = {{Assessment of the Efficacy and Safety of CyberKnife Radiosurgery on Optic Nerve Sheath Meningiomas.}},
author = {Yuhang Wang and Xintong Xu and Shanshan Cao and Mingming Sun and Chunyan Pan and Quangang Xu and Shihui Wei and Zhiqing Li and Longsheng Pan and Huanfen Zhou},
journal = {Vision (Basel, Switzerland)},
year = {2026},
month = oct,
doi = {10.3390/vision10040080},
url = {https://europepmc.org/article/MED/42931618},
note = {CC BY},
}
RIS
TY - JOUR
TI - Assessment of the Efficacy and Safety of CyberKnife Radiosurgery on Optic Nerve Sheath Meningiomas.
AU - Yuhang Wang
AU - Xintong Xu
AU - Shanshan Cao
AU - Mingming Sun
AU - Chunyan Pan
AU - Quangang Xu
AU - Shihui Wei
AU - Zhiqing Li
AU - Longsheng Pan
AU - Huanfen Zhou
PY - 2026
DA - 2026/10/11
JO - Vision (Basel, Switzerland)
DO - 10.3390/vision10040080
UR - https://europepmc.org/article/MED/42931618
AB - The purpose of this study was to evaluate the efficacy and safety of CyberKnife (CK) radiosurgery in patients with optic nerve sheath meningiomas (ONSM). We retrospectively identified patients with ONSM treated with CK between January 2020 and January 2024 from the Database of Chinese Neuro-Ophthalmic Diseases. CK was delivered at 23-25 Gy in 5 fractions. Best-corrected visual acuity (BCVA) and visual field mean deviation (VF MD) were assessed before treatment and at the final follow-up, with a median visual follow-up of 36 months (range, 26-64 months). Tumor volume and CK-related complications were also evaluated. Twenty patients (22 affected eyes; 2 with bilateral involvement) were included. Treatment success was achieved in 90.9% (20/22) of eyes, including improvement in 59.1% (13/22) and stable visual function in 31.8% (7/22), whereas 9.1% (2/22) worsened. Among the 12 eyes with available VF MD data, 91.7% (11/12) improved and 8.3% (1/12) worsened. Spearman correlation analysis revealed that poorer baseline BCVA (r = 0.457, p = 0.032) and a longer interval from onset to CK (r = 0.450, p = 0.036) were associated with poorer visual outcomes, whereas age and tumor volume were not significantly associated with visual changes (p > 0.05). MRI follow-up was available for 13 patients (14 eyes), with tumor control achieved in all 14 eyes. No serious treatment-related complications were observed. CK hypofractionated radiosurgery may preserve and improve visual function in ONSM, providing a potentially safe and effective treatment option.
SN - 2411-5150
ER -