Cutaneous Neoplasms with Sebaceous Differentiation: A Comprehensive Update on Clinical, Histopathological and Molecular Classification.
4 affiliations
- 1Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA.
- 2Department of Pathology, Clinique Universitaire Saint-Luc, Université Catholique de Louvain (UCLouvain), 1200 Brussels, Belgium.
- 3Experimental Medicine Unit, de Duve Institute, Université Catholique de Louvain (UCLouvain), 1200 Brussels, Belgium.
- 4Somatic Functional Genomics and Cancer, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
Abstract
Cutaneous sebaceous neoplasms are rare adnexal tumours differentiated towards sebaceous glands, spanning a biological spectrum from benign (sebaceous adenoma, sebaceoma, nevus sebaceus) to outright malignant (sebaceous carcinoma). Most tumours are sporadic and solitary, with a predilection for the head and neck of elderly adults, but a clinically important subset is observed in the setting of Lynch syndrome/Muir-Torre syndrome. Recent large-scale genomic and transcriptomic studies have provided insights into the pathogenesis of these unique neoplasms, revealing a genetically heterogeneous landscape shaped by mismatch repair deficiency, UV damage, and abnormalities in several other key signalling pathways. The inclusion of nevus sebaceus within the sebaceous tumour family in the WHO 5th Edition of Skin Tumours reflects a conceptual shift, recognising nevus sebaceus as a clonal, mutation-driven neoplasm and a precursor lesion for secondary tumour development.
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BibTeX
@article{wiedemeyer2026cutaneous,
title = {{Cutaneous Neoplasms with Sebaceous Differentiation: A Comprehensive Update on Clinical, Histopathological and Molecular Classification.}},
author = {Katharina Wiedemeyer and Ingrid Ferreira and David J Adams and Thomas Brenn},
journal = {Cancers},
year = {2026},
month = oct,
doi = {10.3390/cancers18193209},
url = {https://europepmc.org/article/MED/42882904},
note = {CC BY},
}
RIS
TY - JOUR
TI - Cutaneous Neoplasms with Sebaceous Differentiation: A Comprehensive Update on Clinical, Histopathological and Molecular Classification.
AU - Katharina Wiedemeyer
AU - Ingrid Ferreira
AU - David J Adams
AU - Thomas Brenn
PY - 2026
DA - 2026/10/04
JO - Cancers
DO - 10.3390/cancers18193209
UR - https://europepmc.org/article/MED/42882904
AB - Cutaneous sebaceous neoplasms are rare adnexal tumours differentiated towards sebaceous glands, spanning a biological spectrum from benign (sebaceous adenoma, sebaceoma, nevus sebaceus) to outright malignant (sebaceous carcinoma). Most tumours are sporadic and solitary, with a predilection for the head and neck of elderly adults, but a clinically important subset is observed in the setting of Lynch syndrome/Muir-Torre syndrome. Recent large-scale genomic and transcriptomic studies have provided insights into the pathogenesis of these unique neoplasms, revealing a genetically heterogeneous landscape shaped by mismatch repair deficiency, UV damage, and abnormalities in several other key signalling pathways. The inclusion of nevus sebaceus within the sebaceous tumour family in the WHO 5th Edition of Skin Tumours reflects a conceptual shift, recognising nevus sebaceus as a clonal, mutation-driven neoplasm and a precursor lesion for secondary tumour development.
SN - 2072-6694
ER -