Downregulation of TRMT9B and its association with clinicopathological features in thyroid cancer: an analysis of public datasets.
- 1Faculdade Israelita de Ciências da Saúde Albert Einstein, Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.
- 2Laboratório de Hormônios e Genética Molecular LIM/42, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.
- 3Institute of Biomedical Sciences, Department of Cell and Developmental Biology, Universidade de São Paulo, São Paulo, SP, Brazil.
Abstract
Objective
To investigate the association between TRMT9B expression and clinicopathological features in thyroid carcinoma.Methods
TRMT9B mRNA expression was analyzed using The Cancer Genome Atlas Thyroid Cancer (TCGA-THCA) and Genotype-Tissue Expression (GTEx) datasets as well as six independent Gene Expression Omnibus (GEO) datasets. Protein-level data were obtained from The Human Protein Atlas. Associations between TRMT9B expression and clinicopathological parameters were evaluated in the TCGA cohort.Results
TRMT9B mRNA was significantly downregulated in thyroid tumors compared with normal tissues across multiple cohorts. In the TCGA cohort, lower TRMT9B expression was significantly correlated with advanced T stage, lymph node involvement, and aggressive histological variants of papillary thyroid carcinoma. Immunohistochemistry data qualitatively supported these findings: protein staining was lower in tumor samples than in healthy tissue.Conclusion
TRMT9B is downregulated in thyroid carcinoma and is associated with markers of disease progression. These findings suggest that TRMT9B plays a role in thyroid tumor biology. Further functional studies are required to clarify its mechanisms and potential clinical utility as a biomarker.
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BibTeX
@article{souza2026downregulation,
title = {{Downregulation of TRMT9B and its association with clinicopathological features in thyroid cancer: an analysis of public datasets.}},
author = {Isadora Biazon de Souza and Larissa Mikalauskas and Felipe Yuji Koyama Azeka and Alexander de Moraes Frankiw and Nathan Mignella Greco and Maria Alice Kawashita Dalla Vecchia and Helena Panteliou Lima-Valassi and Alessandra Valéria de Sousa Faria},
journal = {Einstein (Sao Paulo, Brazil)},
year = {2026},
month = oct,
doi = {10.31744/einstein_journal/2026ao2165},
url = {https://europepmc.org/article/MED/42912012},
note = {CC BY},
}
RIS
TY - JOUR
TI - Downregulation of TRMT9B and its association with clinicopathological features in thyroid cancer: an analysis of public datasets.
AU - Isadora Biazon de Souza
AU - Larissa Mikalauskas
AU - Felipe Yuji Koyama Azeka
AU - Alexander de Moraes Frankiw
AU - Nathan Mignella Greco
AU - Maria Alice Kawashita Dalla Vecchia
AU - Helena Panteliou Lima-Valassi
AU - Alessandra Valéria de Sousa Faria
PY - 2026
DA - 2026/10/19
JO - Einstein (Sao Paulo, Brazil)
DO - 10.31744/einstein_journal/2026ao2165
UR - https://europepmc.org/article/MED/42912012
AB - Objective To investigate the association between TRMT9B expression and clinicopathological features in thyroid carcinoma.Methods TRMT9B mRNA expression was analyzed using The Cancer Genome Atlas Thyroid Cancer (TCGA-THCA) and Genotype-Tissue Expression (GTEx) datasets as well as six independent Gene Expression Omnibus (GEO) datasets. Protein-level data were obtained from The Human Protein Atlas. Associations between TRMT9B expression and clinicopathological parameters were evaluated in the TCGA cohort.Results TRMT9B mRNA was significantly downregulated in thyroid tumors compared with normal tissues across multiple cohorts. In the TCGA cohort, lower TRMT9B expression was significantly correlated with advanced T stage, lymph node involvement, and aggressive histological variants of papillary thyroid carcinoma. Immunohistochemistry data qualitatively supported these findings: protein staining was lower in tumor samples than in healthy tissue.Conclusion TRMT9B is downregulated in thyroid carcinoma and is associated with markers of disease progression. These findings suggest that TRMT9B plays a role in thyroid tumor biology. Further functional studies are required to clarify its mechanisms and potential clinical utility as a biomarker.
SN - 1679-4508
SN - 2317-6385
ER -