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Peer-reviewedCC BY-NC-NDDevelopmental psychology

Prenatal Vitamin C Supplementation Mediates the Association between Prenatal Distress and Infant Negative Affect: A Prospective Cohort Study

  • Elizabeth K. Wood1,2
  • Hailey E. Volk1
  • Elizabeth K. Nousen1,2
  • Olivia K. Nomura1,2
  • Amanda N. Howery1,2
  • Angela M. Horgan3
  • Joel T. Nigg1,2
  • Hanna C. Gustafsson1,2
  • Elinor L. Sullivan1,2
  1. 1Department of Psychiatry, Oregon Health & Science University, Portland, OR 97239
  2. 2Center for Mental Health Innovation, Oregon Health & Science University, Portland, OR 97239
  3. 3Clinical & Translational Research Center, Oregon Health & Science University, Portland OR 97239
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Abstract

= .001). Adjusting for covariates, structural equation modeling showed that prenatal vitamin C supplementation, but not dietary vitamin C intake, mediated the association between maternal prenatal distress and infant NA (indirect β = .02, bootstrapped 95% conifidence interval [0.01, 0.05]). As such, lower vitamin C intake during pregnancy may influence fetal neurodevelopment via altering the intrauterine environment. These findings point to prenatal vitamin C supplementation's potential as a modifiable and scalable intervention to promote healthy early socioemotional development. (PsycInfo Database Record (c) 2026 APA, all rights reserved).

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Cite

BibTeXRIS
BibTeX
@article{wood2026prenatal,
  title = {{Prenatal Vitamin C Supplementation Mediates the Association between Prenatal Distress and Infant Negative Affect: A Prospective Cohort Study}},
  author = {Elizabeth K. Wood and Hailey E. Volk and Elizabeth K. Nousen and Olivia K. Nomura and Amanda N. Howery and Angela M. Horgan and Joel T. Nigg and Hanna C. Gustafsson and Elinor L. Sullivan},
  journal = {Developmental psychology},
  year = {2026},
  month = nov,
  doi = {10.1037/dev0002263},
  url = {https://doi.org/10.1037/dev0002263},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - Prenatal Vitamin C Supplementation Mediates the Association between Prenatal Distress and Infant Negative Affect: A Prospective Cohort Study
AU  - Elizabeth K. Wood
AU  - Hailey E. Volk
AU  - Elizabeth K. Nousen
AU  - Olivia K. Nomura
AU  - Amanda N. Howery
AU  - Angela M. Horgan
AU  - Joel T. Nigg
AU  - Hanna C. Gustafsson
AU  - Elinor L. Sullivan
PY  - 2026
DA  - 2026/11/02
JO  - Developmental psychology
DO  - 10.1037/dev0002263
UR  - https://doi.org/10.1037/dev0002263
AB  - = .001). Adjusting for covariates, structural equation modeling showed that prenatal vitamin C supplementation, but not dietary vitamin C intake, mediated the association between maternal prenatal distress and infant NA (indirect β = .02, bootstrapped 95% conifidence interval [0.01, 0.05]). As such, lower vitamin C intake during pregnancy may influence fetal neurodevelopment via altering the intrauterine environment. These findings point to prenatal vitamin C supplementation's potential as a modifiable and scalable intervention to promote healthy early socioemotional development. (PsycInfo Database Record (c) 2026 APA, all rights reserved).
SN  - 0012-1649
SN  - 1939-0599
ER  -