Age-Associated Decrease of the Histone Methyltransferase SUV39H1 in HSC Perturbs Heterochromatin and B Lymphoid Differentiation
Abstract
The capacity of hematopoietic stem cells (HSC) to generate B lymphocytes declines with age, contributing to impaired immune function in the elderly. Here we show that the histone methyltransferase SUV39H1 plays an important role in human B lymphoid differentiation and that expression of SUV39H1 decreases with age in both human and mouse HSC, leading to a global reduction in H3K9 trimethylation and perturbed heterochromatin function. Further, we demonstrate that SUV39H1 is a target of microRNA miR-125b, a known regulator of HSC function, and that expression of miR-125b increases with age in human HSC. Overexpression of miR-125b and inhibition of SUV39H1 in young HSC induced loss of B cell potential. Conversely, both inhibition of miR-125 and enforced expression of SUV39H1 improved the capacity of HSC from elderly individuals to generate B cells. Our findings highlight the importance of heterochromatin regulation in HSC aging and B lymphopoiesis.
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BibTeX
@article{djeghloul2026ageassociated,
title = {{Age-Associated Decrease of the Histone Methyltransferase SUV39H1 in HSC Perturbs Heterochromatin and B Lymphoid Differentiation}},
author = {Dounia Djeghloul and Klaudia Kuranda and Isabelle Kuzniak and Daniela Barbieri and Irina Naguibneva and Caroline Choisy and Jean-Christophe Bories and Christine Dosquet and Marika Pla and Valérie Vanneaux and Gérard Socié and Françoise Porteu and David Garrick and Michele Goodhardt},
journal = {Stem Cell Reports},
year = {2026},
month = oct,
doi = {10.1016/j.stemcr.2016.05.007},
url = {https://hal.science/hal-05830716v1},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Age-Associated Decrease of the Histone Methyltransferase SUV39H1 in HSC Perturbs Heterochromatin and B Lymphoid Differentiation
AU - Dounia Djeghloul
AU - Klaudia Kuranda
AU - Isabelle Kuzniak
AU - Daniela Barbieri
AU - Irina Naguibneva
AU - Caroline Choisy
AU - Jean-Christophe Bories
AU - Christine Dosquet
AU - Marika Pla
AU - Valérie Vanneaux
AU - Gérard Socié
AU - Françoise Porteu
AU - David Garrick
AU - Michele Goodhardt
PY - 2026
DA - 2026/10/21
JO - Stem Cell Reports
DO - 10.1016/j.stemcr.2016.05.007
UR - https://hal.science/hal-05830716v1
AB - The capacity of hematopoietic stem cells (HSC) to generate B lymphocytes declines with age, contributing to impaired immune function in the elderly. Here we show that the histone methyltransferase SUV39H1 plays an important role in human B lymphoid differentiation and that expression of SUV39H1 decreases with age in both human and mouse HSC, leading to a global reduction in H3K9 trimethylation and perturbed heterochromatin function. Further, we demonstrate that SUV39H1 is a target of microRNA miR-125b, a known regulator of HSC function, and that expression of miR-125b increases with age in human HSC. Overexpression of miR-125b and inhibition of SUV39H1 in young HSC induced loss of B cell potential. Conversely, both inhibition of miR-125 and enforced expression of SUV39H1 improved the capacity of HSC from elderly individuals to generate B cells. Our findings highlight the importance of heterochromatin regulation in HSC aging and B lymphopoiesis.
SN - 2213-6711
ER -