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Peer-reviewedCC BY-NC-NDMalaria journal

Severe Plasmodium falciparum infection with multi-organ involvement in an asplenic patient: a case report.

  • Bolette Wittenberg1
  • Gitte Nyvang Hartmeyer2
  • David Fuglsang-Damgaard3
  • Torsten Roed4
  • Helle Hansson5,6
  • Fredrikke Christie Knudtzen7
7 affiliations
  1. 1Department of Clinical Microbiology, Odense University Hospital, J. B. Winsloews Vej 4, 5000, Odense C, Denmark. [email protected].
  2. 2Department of Clinical Microbiology, Odense University Hospital, J. B. Winsloews Vej 4, 5000, Odense C, Denmark.
  3. 3Department of Clinical Microbiology, Aalborg University Hospital, Aalborg, Denmark.
  4. 4Department of Infectious Diseases, Aalborg University Hospital, Aalborg, Denmark.
  5. 5Center for Translational Medicine and Parasitology, Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark.
  6. 6Department of Infectious Diseases, Copenhagen University Hospital, Copenhagen, Denmark.
  7. 7Clinical Center for Emerging and Vector Borne Infections, Department of Infectious Diseases, Odense University Hospital, Odense, Denmark.
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Abstract

Plasmodium falciparum is the leading cause of severe malaria. The spleen plays a central role in the clearance of the infection in conjunction with antimalarial treatment. Splenectomized patients lack sufficient clearance functions. We report a case of severe P. falciparum infection with multi-organ involvement acquired in Uganda in a splenectomized patient with a persistently high parasitemia level despite appropriate antimalarial treatment. The case emphasizes the challenges associated with severe malaria in asplenic patients.

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Cite

BibTeXRIS
BibTeX
@article{wittenberg2026severe,
  title = {{Severe Plasmodium falciparum infection with multi-organ involvement in an asplenic patient: a case report.}},
  author = {Bolette Wittenberg and Gitte Nyvang Hartmeyer and David Fuglsang-Damgaard and Torsten Roed and Helle Hansson and Fredrikke Christie Knudtzen},
  journal = {Malaria journal},
  year = {2026},
  month = aug,
  doi = {10.1186/s12936-026-06079-5},
  url = {https://europepmc.org/article/MED/42919362},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - Severe Plasmodium falciparum infection with multi-organ involvement in an asplenic patient: a case report.
AU  - Bolette Wittenberg
AU  - Gitte Nyvang Hartmeyer
AU  - David Fuglsang-Damgaard
AU  - Torsten Roed
AU  - Helle Hansson
AU  - Fredrikke Christie Knudtzen
PY  - 2026
DA  - 2026/08/01
JO  - Malaria journal
DO  - 10.1186/s12936-026-06079-5
UR  - https://europepmc.org/article/MED/42919362
AB  - Plasmodium falciparum is the leading cause of severe malaria. The spleen plays a central role in the clearance of the infection in conjunction with antimalarial treatment. Splenectomized patients lack sufficient clearance functions. We report a case of severe P. falciparum infection with multi-organ involvement acquired in Uganda in a splenectomized patient with a persistently high parasitemia level despite appropriate antimalarial treatment. The case emphasizes the challenges associated with severe malaria in asplenic patients.
SN  - 1475-2875
ER  -