Revisiting common female infertility factors traditionally associated with impaired oocyte quality: insights from IVF outcomes and AI-derived oocyte score performance
4 affiliations
- 1Instituto Sapientiae
- 2Science for Everymind
- 3Fertility/FERTGROUP- Medicina Reprodutiva
- 4Future Fertility
Abstract
Background: While advanced maternal age is consistently associated with impaired oocyte competence and poorer reproductive outcomes, the effects of other female infertility factors, including polyendocrine metabolic ovarian syndrome (PMOS), endometriosis, and body mass index (BMI), remain debated. Moreover, whether AI-derived oocyte quality metrics retain their predictive value across different female infertility conditions remains unclear.
Methods: This retrospective cohort study evaluated whether common female infertility factors are associated with oocyte and embryo competence and cumulative reproductive outcomes in intracytoplasmic sperm injection (ICSI) cycles, and assessed the performance of an AI-derived composite oocyte score across these populations. The study included 14,420 injected oocytes from 1,856 autologous ICSI cycles performed between 2020 and 2025. Outcomes were compared between controls and women with polyendocrine metabolic ovarian syndrome (PMOS), endometriosis, overweight, or obesity; controls were additionally stratified by maternal age (<38 versus ≥38 years). Age-based propensity-score weighting was applied for pairwise female-factor comparisons, followed by adjusted mixed-effects regression models accounting for patient- and retrieval-cycle-level clustering.
Results: Endometriosis and obesity were not associated with consistent reductions in laboratory or clinical outcomes, whereas overweight was associated with lower top-quality blastocyst and cumulative reproductive outcomes. Advanced maternal age showed the most consistent detrimental pattern, including lower MAGENTA and KIDScore values, reduced blastocyst development and euploidy rates, and lower cumulative pregnancy rates. PMOS cycles showed largely preserved laboratory outcomes, higher MII yield, and higher observed cumulative pregnancy rates. The composite MAGENTA score was associated with higher odds of fertilization (OR 1.53), blastocyst formation (OR 1.67), and top-quality blastocyst formation (OR 1.26), and with higher KIDScore (β = 0.21). These associations were generally observed across the evaluated female-factor groups, and MAGENTA provided modest incremental discrimination beyond clinical variables.
Discussion: Overall, female infertility factors appear to affect reproductive competence through distinct patterns rather than a uniform impairment in oocyte quality, with maternal age showing the most consistent adverse association and AI-derived oocyte assessment providing complementary predictive information across heterogeneous populations.
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BibTeX
@article{collado2026revisiting,
title = {{Revisiting common female infertility factors traditionally associated with impaired oocyte quality: insights from IVF outcomes and AI-derived oocyte score performance}},
author = {Maite del Collado and Daniela Paes de Almeida Ferreira Braga and Amanda Souza Setti and Lais Vanzella and Jullin Fjeldstad and Parisa Mojiri and Edson Borges},
journal = {Frontiers in Endocrinology},
year = {2026},
month = nov,
doi = {10.3389/fendo.2026.1957168},
url = {https://www.frontiersin.org/articles/10.3389/fendo.2026.1957168/full},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Revisiting common female infertility factors traditionally associated with impaired oocyte quality: insights from IVF outcomes and AI-derived oocyte score performance
AU - Maite del Collado
AU - Daniela Paes de Almeida Ferreira Braga
AU - Amanda Souza Setti
AU - Lais Vanzella
AU - Jullin Fjeldstad
AU - Parisa Mojiri
AU - Edson Borges
PY - 2026
DA - 2026/11/04
JO - Frontiers in Endocrinology
DO - 10.3389/fendo.2026.1957168
UR - https://www.frontiersin.org/articles/10.3389/fendo.2026.1957168/full
AB - Background: While advanced maternal age is consistently associated with impaired oocyte competence and poorer reproductive outcomes, the effects of other female infertility factors, including polyendocrine metabolic ovarian syndrome (PMOS), endometriosis, and body mass index (BMI), remain debated. Moreover, whether AI-derived oocyte quality metrics retain their predictive value across different female infertility conditions remains unclear. Methods: This retrospective cohort study evaluated whether common female infertility factors are associated with oocyte and embryo competence and cumulative reproductive outcomes in intracytoplasmic sperm injection (ICSI) cycles, and assessed the performance of an AI-derived composite oocyte score across these populations. The study included 14,420 injected oocytes from 1,856 autologous ICSI cycles performed between 2020 and 2025. Outcomes were compared between controls and women with polyendocrine metabolic ovarian syndrome (PMOS), endometriosis, overweight, or obesity; controls were additionally stratified by maternal age (<38 versus ≥38 years). Age-based propensity-score weighting was applied for pairwise female-factor comparisons, followed by adjusted mixed-effects regression models accounting for patient- and retrieval-cycle-level clustering. Results: Endometriosis and obesity were not associated with consistent reductions in laboratory or clinical outcomes, whereas overweight was associated with lower top-quality blastocyst and cumulative reproductive outcomes. Advanced maternal age showed the most consistent detrimental pattern, including lower MAGENTA and KIDScore values, reduced blastocyst development and euploidy rates, and lower cumulative pregnancy rates. PMOS cycles showed largely preserved laboratory outcomes, higher MII yield, and higher observed cumulative pregnancy rates. The composite MAGENTA score was associated with higher odds of fertilization (OR 1.53), blastocyst formation (OR 1.67), and top-quality blastocyst formation (OR 1.26), and with higher KIDScore (β = 0.21). These associations were generally observed across the evaluated female-factor groups, and MAGENTA provided modest incremental discrimination beyond clinical variables. Discussion: Overall, female infertility factors appear to affect reproductive competence through distinct patterns rather than a uniform impairment in oocyte quality, with maternal age showing the most consistent adverse association and AI-derived oocyte assessment providing complementary predictive information across heterogeneous populations.
SN - 1664-2392
ER -