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Peer-reviewedCC BY-NCChemistry & biodiversity

Pentahydroxyflavone and Metformin Mitigate Diabetes-Induced Hepatic Dysfunction in Gamma-Irradiated Rats Through the AMPK-SREBP-1c-SCD1 Pathway.

  • Hanaa F B Gaber1
  • Fatma S M Moawed2
  • Mohamed K Mahfouz1
  • Esraa S A Ahmed3
  • Omayma A R Abo-Zaid1
  1. 1Biochemistry and Molecular Biology Department, Faculty of Veterinary Medicine, Benha University, Al-Qalyubia, Egypt.
  2. 2Health Radiation Research, National Center for Radiation Research and Technology, Egyptian Atomic Energy Authority, Cairo, Egypt.
  3. 3Radiation Biology Research, National Center for Radiation Research and Technology, Egyptian Atomic Energy Authority, Cairo, Egypt.
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Abstract

Diabetes mellitus (DM) is a common complication among cancer patients, potentially worsening the adverse effects of radiation therapy. This study aimed to evaluate whether pentahydroxy flavone (PHF) and Metformin (MET) could mitigate liver damage associated with streptozotocin (STZ)-induced diabetes in rats exposed to gamma irradiation (IR). Diabetes was induced in rats by a single dose of STZ (35 mg/kg) and exposure to a cumulative IR dose (4 Gy). Over one month, each treatment group received either PHF (50 mg/kg) or MET (200 mg/kg). Combined treatment with PHF and MET improved lipid profiles, reduced insulin resistance, coupled with diminishing hepatic inflammation (NLRC4) and oxidative stress. Furthermore, co-administration of PHF and MET modulated the AMPK/ SREBP1c/ SCD1-related signaling, ameliorating hepatic steatosis and fibrosis. These findings suggest that PHF combined with MET's could serve as an adjuvant therapy alongside MET to protect against liver damage caused by diabetes and gamma radiation.

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Cite

BibTeXRIS
BibTeX
@article{gaber2026pentahydroxyflavone,
  title = {{Pentahydroxyflavone and Metformin Mitigate Diabetes-Induced Hepatic Dysfunction in Gamma-Irradiated Rats Through the AMPK-SREBP-1c-SCD1 Pathway.}},
  author = {Hanaa F B Gaber and Fatma S M Moawed and Mohamed K Mahfouz and Esraa S A Ahmed and Omayma A R Abo-Zaid},
  journal = {Chemistry \& biodiversity},
  year = {2026},
  month = oct,
  doi = {10.1002/cbdv.71801},
  url = {https://europepmc.org/article/MED/42902859},
  note = {CC BY-NC},
}
RIS
TY  - JOUR
TI  - Pentahydroxyflavone and Metformin Mitigate Diabetes-Induced Hepatic Dysfunction in Gamma-Irradiated Rats Through the AMPK-SREBP-1c-SCD1 Pathway.
AU  - Hanaa F B Gaber
AU  - Fatma S M Moawed
AU  - Mohamed K Mahfouz
AU  - Esraa S A Ahmed
AU  - Omayma A R Abo-Zaid
PY  - 2026
DA  - 2026/10/01
JO  - Chemistry & biodiversity
DO  - 10.1002/cbdv.71801
UR  - https://europepmc.org/article/MED/42902859
AB  - Diabetes mellitus (DM) is a common complication among cancer patients, potentially worsening the adverse effects of radiation therapy. This study aimed to evaluate whether pentahydroxy flavone (PHF) and Metformin (MET) could mitigate liver damage associated with streptozotocin (STZ)-induced diabetes in rats exposed to gamma irradiation (IR). Diabetes was induced in rats by a single dose of STZ (35 mg/kg) and exposure to a cumulative IR dose (4 Gy). Over one month, each treatment group received either PHF (50 mg/kg) or MET (200 mg/kg). Combined treatment with PHF and MET improved lipid profiles, reduced insulin resistance, coupled with diminishing hepatic inflammation (NLRC4) and oxidative stress. Furthermore, co-administration of PHF and MET modulated the AMPK/ SREBP1c/ SCD1-related signaling, ameliorating hepatic steatosis and fibrosis. These findings suggest that PHF combined with MET's could serve as an adjuvant therapy alongside MET to protect against liver damage caused by diabetes and gamma radiation.
SN  - 1612-1872
SN  - 1612-1880
ER  -